TY - JOUR TI - A comprehensive review of randomized clinical trials in three medical journals reveals 396 medical reversals AU - Herrera-Perez, Diana AU - Haslam, Alyson AU - Crain, Tyler AU - Gill, Jennifer AU - Livingston, Catherine AU - Kaestner, Victoria AU - Hayes, Michael AU - Morgan, Dan AU - Cifu, Adam S AU - Prasad, Vinay A2 - Franco, Eduardo A2 - Elshaug, Adam VL - 8 PY - 2019 DA - 2019/06/11 SP - e45183 C1 - eLife 2019;8:e45183 DO - 10.7554/eLife.45183 UR - https://doi.org/10.7554/eLife.45183 AB - The ability to identify medical reversals and other low-value medical practices is an essential prerequisite for efforts to reduce spending on such practices. Through an analysis of more than 3000 randomized controlled trials (RCTs) published in three leading medical journals (the Journal of the American Medical Association, the Lancet, and the New England Journal of Medicine), we have identified 396 medical reversals. Most of the studies (92%) were conducted on populations in high-income countries, cardiovascular disease was the most common medical category (20%), and medication was the most common type of intervention (33%). KW - low-value care KW - medical reversal KW - evidence-based medicine JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -