TY - JOUR TI - Mapping sequence structure in the human lateral entorhinal cortex AU - Bellmund, Jacob LS AU - Deuker, Lorena AU - Doeller, Christian F A2 - Momennejad, Ida A2 - Behrens, Timothy E A2 - Howard, Marc A2 - Ólafsdóttir, H Freyja VL - 8 PY - 2019 DA - 2019/08/06 SP - e45333 C1 - eLife 2019;8:e45333 DO - 10.7554/eLife.45333 UR - https://doi.org/10.7554/eLife.45333 AB - Remembering event sequences is central to episodic memory and presumably supported by the hippocampal-entorhinal region. We previously demonstrated that the hippocampus maps spatial and temporal distances between events encountered along a route through a virtual city (Deuker et al., 2016), but the content of entorhinal mnemonic representations remains unclear. Here, we demonstrate that multi-voxel representations in the anterior-lateral entorhinal cortex (alEC) — the human homologue of the rodent lateral entorhinal cortex — specifically reflect the temporal event structure after learning. Holistic representations of the sequence structure related to memory recall and the timeline of events could be reconstructed from entorhinal multi-voxel patterns. Our findings demonstrate representations of temporal structure in the alEC; dovetailing with temporal information carried by population signals in the lateral entorhinal cortex of navigating rodents and alEC activations during temporal memory retrieval. Our results provide novel evidence for the role of the alEC in representing time for episodic memory. KW - episodic memory KW - entorhinal cortex KW - fMRI KW - time KW - virtual reality KW - memory JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -