TY - JOUR TI - Cortico-hippocampal network connections support the multidimensional quality of episodic memory AU - Cooper, Rose A AU - Ritchey, Maureen A2 - Irish, Muireann A2 - Colgin, Laura VL - 8 PY - 2019 DA - 2019/03/22 SP - e45591 C1 - eLife 2019;8:e45591 DO - 10.7554/eLife.45591 UR - https://doi.org/10.7554/eLife.45591 AB - Episodic memories reflect a bound representation of multimodal features that can be reinstated with varying precision. Yet little is known about how brain networks involved in memory, including the hippocampus and posterior-medial (PM) and anterior-temporal (AT) systems, interact to support the quality and content of recollection. Participants learned color, spatial, and emotion associations of objects, later reconstructing the visual features using a continuous color spectrum and 360-degree panorama scenes. Behaviorally, dependencies in memory were observed for the gist but not precision of event associations. Supporting this integration, hippocampus, AT, and PM regions showed increased connectivity and reduced modularity during retrieval compared to encoding. These inter-network connections tracked a multidimensional, objective measure of memory quality. Moreover, distinct patterns of connectivity tracked item color and spatial memory precision. These findings demonstrate how hippocampal-cortical connections reconfigure during episodic retrieval, and how such dynamic interactions might flexibly support the multidimensional quality of remembered events. KW - episodic memory KW - hippocampus KW - functional connectivity KW - cortical networks KW - memory precision KW - spatial memory JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -