1. Chromosomes and Gene Expression
  2. Genetics and Genomics
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Noncoding RNA: Aging well with Norad

  1. Filipa Carvalhal Marques  Is a corresponding author
  2. Igor Ulitsky  Is a corresponding author
  1. The Weizmann Institute of Science, Israel
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Cite this article as: eLife 2019;8:e45974 doi: 10.7554/eLife.45974
1 figure

Figures

The Norad-PUMILIO axis.

The long noncoding RNA Norad (top) can bind to the PUMILIO proteins PUM1 (pale blue) and PUM2 (pale green) and repress their activity (Lee et al., 2016; Tichon et al., 2016). PUM1 and PUM2 also inhibit each other, and they may repress Norad (dotted inhibitory arrow; Goldstrohm et al., 2018). In mice that are genetically engineered to lack Norad or to overproduce PUM2, PUMILIO proteins become overactive and strongly inhibit molecules that prevent damage to mitochondria (bottom dark and light gray structure), as well as molecules that prevent cells from acquiring the wrong number of chromosomes (aneuploidy). As a result, these mice show accelerated aging (bottom; Kopp et al., 2019).

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