TY - JOUR TI - Novel long-range inhibitory nNOS-expressing hippocampal cells AU - Christenson Wick, ZoƩ AU - Tetzlaff, Madison R AU - Krook-Magnuson, Esther A2 - Scharfman, Helen A2 - Colgin, Laura L VL - 8 PY - 2019 DA - 2019/10/14 SP - e46816 C1 - eLife 2019;8:e46816 DO - 10.7554/eLife.46816 UR - https://doi.org/10.7554/eLife.46816 AB - The hippocampus, a brain region that is important for spatial navigation and episodic memory, benefits from a rich diversity of neuronal cell-types. Through the use of an intersectional genetic viral vector approach in mice, we report novel hippocampal neurons which we refer to as LINCs, as they are long-range inhibitory neuronal nitric oxide synthase (nNOS)-expressing cells. LINCs project to several extrahippocampal regions including the tenia tecta, diagonal band, and retromammillary nucleus, but also broadly target local CA1 cells. LINCs are thus both interneurons and projection neurons. LINCs display regular spiking non-pyramidal firing patterns, are primarily located in the stratum oriens or pyramidale, have sparsely spiny dendrites, and do not typically express somatostatin, VIP, or the muscarinic acetylcholine receptor M2. We further demonstrate that LINCs can strongly influence hippocampal function and oscillations, including interregional coherence. The identification and characterization of these novel cells advances our basic understanding of both hippocampal circuitry and neuronal diversity. KW - nNOS KW - INTRSECT KW - oscillation KW - coherence KW - frontal cortex KW - tenia tecta JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -