1. Evolutionary Biology
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Stem Cells: Getting to the heart of cardiovascular evolution in humans

  1. Alex Pollen  Is a corresponding author
  2. Bryan J Pavlovic
  1. University of California, San Francisco, United States
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Cite this article as: eLife 2019;8:e47807 doi: 10.7554/eLife.47807
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Using stem cell models to explore the genetic effects that influence susceptibility to cardiovascular disease.

Ward and Gilad explored the effects of hypoxia (that is, oxygen deprivation) on cardiomyocytes (heart cells derived from stem cells) from humans and chimpanzees. They found that 75% of the genes that respond to hypoxia respond in the same way in both species (third panel). They also observed a large overlap between these conserved response genes and genes that are upregulated in patients with ischemia (fourth panel; left), but little overlap with eQTL genes (right).

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