TY - JOUR TI - Dzip1 and Fam92 form a ciliary transition zone complex with cell type specific roles in Drosophila AU - Lapart, Jean-André AU - Gottardo, Marco AU - Cortier, Elisabeth AU - Duteyrat, Jean-Luc AU - Augière, Céline AU - Mangé, Alain AU - Jerber, Julie AU - Solassol, Jérôme AU - Gopalakrishnan, Jay AU - Thomas, Joëlle AU - Durand, Bénédicte A2 - Sengupta, Piali A2 - Akhmanova, Anna VL - 8 PY - 2019 DA - 2019/12/10 SP - e49307 C1 - eLife 2019;8:e49307 DO - 10.7554/eLife.49307 UR - https://doi.org/10.7554/eLife.49307 AB - Cilia and flagella are conserved eukaryotic organelles essential for cellular signaling and motility. Cilia dysfunctions cause life-threatening ciliopathies, many of which are due to defects in the transition zone (TZ), a complex structure of the ciliary base. Therefore, understanding TZ assembly, which relies on ordered interactions of multiprotein modules, is of critical importance. Here, we show that Drosophila Dzip1 and Fam92 form a functional module which constrains the conserved core TZ protein, Cep290, to the ciliary base. We identify cell type specific roles of this functional module in two different tissues. While it is required for TZ assembly in all Drosophila ciliated cells, it also regulates basal-body growth and docking to the plasma membrane during spermatogenesis. We therefore demonstrate a novel regulatory role for Dzip1 and Fam92 in mediating membrane/basal-body interactions and show that these interactions exhibit cell type specific functions in basal-body maturation and TZ organization. KW - cilia KW - basal body KW - ciliopathies JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -