TY - JOUR TI - Stimulating the hippocampal posterior-medial network enhances task-dependent connectivity and memory AU - Warren, Kristen N AU - Hermiller, Molly S AU - Nilakantan, Aneesha S AU - Voss, Joel L A2 - Barense, Morgan A2 - Colgin, Laura L VL - 8 PY - 2019 DA - 2019/11/14 SP - e49458 C1 - eLife 2019;8:e49458 DO - 10.7554/eLife.49458 UR - https://doi.org/10.7554/eLife.49458 AB - Successful episodic memory involves dynamic increases in activity across distributed hippocampal networks, including the posterior-medial (PMN) and the anterior-temporal (ATN) networks. We tested whether this up-regulation of functional connectivity during memory processing can be enhanced within hippocampal networks by noninvasive stimulation, and whether such task-dependent connectivity enhancement predicts memory improvement. Participants received stimulation targeting the PMN or an out-of-network control location. We compared the effects of stimulation on fMRI connectivity during an autobiographical retrieval task versus during rest within the PMN and the ATN. PMN-targeted stimulation significantly increased connectivity during autobiographical retrieval versus rest within the PMN. This effect was not observed in the ATN, or in either network following control stimulation. Task-dependent increases in connectivity within the medial temporal lobe predicted improved performance of a separate episodic memory test. It is therefore possible to enhance the task-dependent regulation of hippocampal network connectivity that supports memory processing using noninvasive stimulation. KW - episodic memory KW - functional connectivity KW - autobiographical memory KW - resting state KW - transcranial magnetic stimulation JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -