TY - JOUR TI - MouseBytes, an open-access high-throughput pipeline and database for rodent touchscreen-based cognitive assessment AU - Beraldo, Flavio H AU - Palmer, Daniel AU - Memar, Sara AU - Wasserman, David I AU - Lee, Wai-Jane V AU - Liang, Shuai AU - Creighton, Samantha D AU - Kolisnyk, Benjamin AU - Cowan, Matthew F AU - Mels, Justin AU - Masood, Talal S AU - Fodor, Chris AU - Al-Onaizi, Mohammed A AU - Bartha, Robert AU - Gee, Tom AU - Saksida, Lisa M AU - Bussey, Timothy J AU - Strother, Stephen S AU - Prado, Vania F AU - Winters, Boyer D AU - Prado, Marco AM A2 - Holmes, Andrew A2 - Zoghbi, Huda Y A2 - Howland, John G A2 - Chudasama, Yogita VL - 8 PY - 2019 DA - 2019/12/11 SP - e49630 C1 - eLife 2019;8:e49630 DO - 10.7554/eLife.49630 UR - https://doi.org/10.7554/eLife.49630 AB - Open Science has changed research by making data accessible and shareable, contributing to replicability to accelerate and disseminate knowledge. However, for rodent cognitive studies the availability of tools to share and disseminate data is scarce. Automated touchscreen-based tests enable systematic cognitive assessment with easily standardised outputs that can facilitate data dissemination. Here we present an integration of touchscreen cognitive testing with an open-access database public repository (mousebytes.ca), as well as a Web platform for knowledge dissemination (https://touchscreencognition.org). We complement these resources with the largest dataset of age-dependent high-level cognitive assessment of mouse models of Alzheimer’s disease, expanding knowledge of affected cognitive domains from male and female mice of three strains. We envision that these new platforms will enhance sharing of protocols, data availability and transparency, allowing meta-analysis and reuse of mouse cognitive data to increase the replicability/reproducibility of datasets. KW - Alzheimer's disease KW - amyloid-beta plaques KW - open-access database KW - touchscreen KW - high-throughput screening KW - cognition JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -