1. Evolutionary Biology
  2. Genetics and Genomics
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Spermatogenesis: A hotspot for new genes

  1. Anne-Marie Dion-Côté  Is a corresponding author
  1. Université de Moncton, Canada
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Cite this article as: eLife 2019;8:e50136 doi: 10.7554/eLife.50136
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New genes are expressed differently depending on spermatogenesis stages.

In the testis of fruit flies, the creation of mature sperm, or spermatogenesis, starts with a germline stem cell going through several rounds of mitosis to form early spermatocytes. After meiosis, these cells become late spermatocytes, which then develop into early and late spermatids. Witt et al. show that fixed de novo genes, which emerge from non-coding sequences, are expressed during mid-spermatogenesis, in particular in early spermatocytes. In contrast, other types of new genes, for example which come from gene duplication, are expressed at different stages.

Image credit: Witt et al., 2019; adapted from Figure 1A (CC BY 4.0).

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