TY - JOUR TI - Experience shapes activity dynamics and stimulus coding of VIP inhibitory cells AU - Garrett, Marina AU - Manavi, Sahar AU - Roll, Kate AU - Ollerenshaw, Douglas R AU - Groblewski, Peter A AU - Ponvert, Nicholas D AU - Kiggins, Justin T AU - Casal, Linzy AU - Mace, Kyla AU - Williford, Ali AU - Leon, Arielle AU - Jia, Xiaoxuan AU - Ledochowitsch, Peter AU - Buice, Michael A AU - Wakeman, Wayne AU - Mihalas, Stefan AU - Olsen, Shawn R A2 - Bathellier, Brice A2 - Gold, Joshua I A2 - Bathellier, Brice A2 - Keller, Georg B VL - 9 PY - 2020 DA - 2020/02/26 SP - e50340 C1 - eLife 2020;9:e50340 DO - 10.7554/eLife.50340 UR - https://doi.org/10.7554/eLife.50340 AB - Cortical circuits can flexibly change with experience and learning, but the effects on specific cell types, including distinct inhibitory types, are not well understood. Here we investigated how excitatory and VIP inhibitory cells in layer 2/3 of mouse visual cortex were impacted by visual experience in the context of a behavioral task. Mice learned a visual change detection task with a set of eight natural scene images. Subsequently, during 2-photon imaging experiments, mice performed the task with these familiar images and three sets of novel images. Strikingly, the temporal dynamics of VIP activity differed markedly between novel and familiar images: VIP cells were stimulus-driven by novel images but were suppressed by familiar stimuli and showed ramping activity when expected stimuli were omitted from a temporally predictable sequence. This prominent change in VIP activity suggests that these cells may adopt different modes of processing under novel versus familiar conditions. KW - visual system KW - behavior KW - learning JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -