Selection on mutators is not frequency-dependent

  1. Yevgeniy Raynes  Is a corresponding author
  2. Daniel Weinreich
  1. Brown University, United States
4 figures and 1 additional file

Figures

Figure 1 with 1 supplement
The sharp transition between fixation and loss in mutator dynamics at different starting frequencies is due to limited sampling.

(A) Changes in the ratio of the mutator and the wild-type alleles of the E. coli mutT locus over time in continuous chemostat cultures. (Figure 1 from Chao and Cox, 1983). (B) In simulations, …

https://doi.org/10.7554/eLife.51177.002
Figure 1—source data 1

Numerical data represented in Figure 1.

Data set includes mutator frequencies in randomly-chosen individual realizationss and mutator frequencies averaged across all realizations.

https://doi.org/10.7554/eLife.51177.005
Figure 1—figure supplement 1
Simulations with exponentially distributed selection coefficients confirm that the frequency-dependent threshold in mutator dynamics is due to limited sampling.

(A) Mutator trajectories in individual realizations. (B) Average mutator trajectories across realizations. Mutator frequencies averaged across 105 simulation runs. Parameter values as in Figure 1

https://doi.org/10.7554/eLife.51177.003
Figure 1—figure supplement 1—source data 1

Numerical data represented in Figure 1—figure supplement 1.

Data set includes mutator frequencies in randomly-chosen individual realizationss and mutator frequencies averaged across all realizations.

https://doi.org/10.7554/eLife.51177.004
Mutator fixation probability is not frequency-dependent.

Fixation probability,  Pfixx0, of a mutator initiated at frequency x0 (circles: orange for x0=1/N, purple for x0>1/N). Data from simulations in Figure 1. Pfixx0 scales with but never crosses the fixation probability …

https://doi.org/10.7554/eLife.51177.006
Figure 2—source data 1

Numerical data represented in Figure 2.

Data set includes fixation probabilities of a mutator allele at each initial frequency shown.

https://doi.org/10.7554/eLife.51177.007
Frequency threshold in dynamics of fitness-affecting mutations.

(A) Individual realizations of a simulation initiated with a directly beneficial mutation of size sben = 0.01 at a starting frequency x0. Population size, N = 107. Inset: Fixation probability of a …

https://doi.org/10.7554/eLife.51177.008
Figure 3—source data 1

Numerical data represented in Figure 3.

Data set includes frequencies of a beneficial mutation and a frequncy-dependent mutation in randomly-chosen individual realizations and averaged across all replicate realizations.

https://doi.org/10.7554/eLife.51177.009
Author response image 1

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