(A) Changes in the ratio of the mutator and the wild-type alleles of the E. coli mutT locus over time in continuous chemostat cultures. (Figure 1 from Chao and Cox, 1983). (B) In simulations, …
Numerical data represented in Figure 1.
Data set includes mutator frequencies in randomly-chosen individual realizationss and mutator frequencies averaged across all realizations.
(A) Mutator trajectories in individual realizations. (B) Average mutator trajectories across realizations. Mutator frequencies averaged across 105 simulation runs. Parameter values as in Figure 1 …
Numerical data represented in Figure 1—figure supplement 1.
Data set includes mutator frequencies in randomly-chosen individual realizationss and mutator frequencies averaged across all realizations.
Fixation probability, of a mutator initiated at frequency (circles: orange for purple for ). Data from simulations in Figure 1. scales with but never crosses the fixation probability …
Numerical data represented in Figure 2.
Data set includes fixation probabilities of a mutator allele at each initial frequency shown.
(A) Individual realizations of a simulation initiated with a directly beneficial mutation of size = 0.01 at a starting frequency . Population size, N = 107. Inset: Fixation probability of a …
Numerical data represented in Figure 3.
Data set includes frequencies of a beneficial mutation and a frequncy-dependent mutation in randomly-chosen individual realizations and averaged across all replicate realizations.