Selection on mutators is not frequency-dependent
- Brown University, United States
Figures
Figure 1 with 1 supplement
The sharp transition between fixation and loss in mutator dynamics at different starting frequencies is due to limited sampling.
(A) Changes in the ratio of the mutator and the wild-type alleles of the E. coli mutT locus over time in continuous chemostat cultures. (Figure 1 from Chao and Cox, 1983). (B) In simulations, …
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Figure 1—source data 1
Numerical data represented in Figure 1.
Data set includes mutator frequencies in randomly-chosen individual realizationss and mutator frequencies averaged across all realizations.
- https://doi.org/10.7554/eLife.51177.005
Figure 1—figure supplement 1
Simulations with exponentially distributed selection coefficients confirm that the frequency-dependent threshold in mutator dynamics is due to limited sampling.
(A) Mutator trajectories in individual realizations. (B) Average mutator trajectories across realizations. Mutator frequencies averaged across 105 simulation runs. Parameter values as in Figure 1 …
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Figure 1—figure supplement 1—source data 1
Numerical data represented in Figure 1—figure supplement 1.
Data set includes mutator frequencies in randomly-chosen individual realizationss and mutator frequencies averaged across all realizations.
- https://doi.org/10.7554/eLife.51177.004
Figure 2
Mutator fixation probability is not frequency-dependent.
Fixation probability, of a mutator initiated at frequency (circles: orange for purple for ). Data from simulations in Figure 1. scales with but never crosses the fixation probability …
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Figure 2—source data 1
Numerical data represented in Figure 2.
Data set includes fixation probabilities of a mutator allele at each initial frequency shown.
- https://doi.org/10.7554/eLife.51177.007
Figure 3
Frequency threshold in dynamics of fitness-affecting mutations.
(A) Individual realizations of a simulation initiated with a directly beneficial mutation of size = 0.01 at a starting frequency . Population size, N = 107. Inset: Fixation probability of a …
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Figure 3—source data 1
Numerical data represented in Figure 3.
Data set includes frequencies of a beneficial mutation and a frequncy-dependent mutation in randomly-chosen individual realizations and averaged across all replicate realizations.
- https://doi.org/10.7554/eLife.51177.009
Author response image 1
Additional files
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Transparent reporting form
- https://doi.org/10.7554/eLife.51177.010
