TY - JOUR TI - Representation of visual landmarks in retrosplenial cortex AU - Fischer, Lukas F AU - Mojica Soto-Albors, Raul AU - Buck, Friederike AU - Harnett, Mark T A2 - Bathellier, Brice A2 - Colgin, Laura L VL - 9 PY - 2020 DA - 2020/03/10 SP - e51458 C1 - eLife 2020;9:e51458 DO - 10.7554/eLife.51458 UR - https://doi.org/10.7554/eLife.51458 AB - The process by which visual information is incorporated into the brain’s spatial framework to represent landmarks is poorly understood. Studies in humans and rodents suggest that retrosplenial cortex (RSC) plays a key role in these computations. We developed an RSC-dependent behavioral task in which head-fixed mice learned the spatial relationship between visual landmark cues and hidden reward locations. Two-photon imaging revealed that these cues served as dominant reference points for most task-active neurons and anchored the spatial code in RSC. This encoding was more robust after task acquisition. Decoupling the virtual environment from mouse behavior degraded spatial representations and provided evidence that supralinear integration of visual and motor inputs contributes to landmark encoding. V1 axons recorded in RSC were less modulated by task engagement but showed surprisingly similar spatial tuning. Our data indicate that landmark representations in RSC are the result of local integration of visual, motor, and spatial information. KW - retrosplenial cortex KW - sensorimotor integration KW - spatial navigation KW - visual cortex KW - population imaging KW - behavior JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -