TY - JOUR TI - Recurrent circuit dynamics underlie persistent activity in the macaque frontoparietal network AU - Hart, Eric AU - Huk, Alexander C A2 - Salinas, Emilio A2 - Behrens, Timothy E A2 - Salinas, Emilio A2 - Compte, Albert VL - 9 PY - 2020 DA - 2020/05/07 SP - e52460 C1 - eLife 2020;9:e52460 DO - 10.7554/eLife.52460 UR - https://doi.org/10.7554/eLife.52460 AB - During delayed oculomotor response tasks, neurons in the lateral intraparietal area (LIP) and the frontal eye fields (FEF) exhibit persistent activity that reflects the active maintenance of behaviorally relevant information. Despite many computational models of the mechanisms of persistent activity, there is a lack of circuit-level data from the primate to inform the theories. To fill this gap, we simultaneously recorded ensembles of neurons in both LIP and FEF while macaques performed a memory-guided saccade task. A population encoding model revealed strong and symmetric long-timescale recurrent excitation between LIP and FEF. Unexpectedly, LIP exhibited stronger local functional connectivity than FEF, and many neurons in LIP had longer network and intrinsic timescales. The differences in connectivity could be explained by the strength of recurrent dynamics in attractor networks. These findings reveal reciprocal multi-area circuit dynamics in the frontoparietal network during persistent activity and lay the groundwork for quantitative comparisons to theoretical models. KW - persistent activity KW - LIP KW - FEF KW - GLM KW - working memory KW - coupling JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -