1. Neuroscience
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Behavior: The cerebellum shows its stripes

  1. Ashley L Holloway
  2. Talia N Lerner  Is a corresponding author
  1. Feinberg School of Medicine, Northwestern University, United States
  2. Northwestern University Interdepartmental Neuroscience (NUIN) Graduate Program, United States
Cite this article as: eLife 2019;8:e52631 doi: 10.7554/eLife.52631
1 figure


How cerebellar Crus II microzones process information during a Go/No-go task.

(A) Schematic of the Go/No-go task. Mice are trained to associate a ‘Go’ cue – here, a 10 kHz tone – with a sweet liquid becoming available, and to react with a licking behavior. The No-go signal (a 4 kHz sound) is not associated with reward. Green arrows indicate a lick response to the signal, and red arrows that there was no lick response. A lick response to the Go tone was rewarded with food (‘hit’), and a lick response to a No-go tone (‘false alarm’) was punished with a time-out. (B) Relative activity of the dendrites of Purkinje cells in response to a 10 kHz Go tone. The pink trace shows the response of dendrites from an AldC+ cell (which expresses the enzyme Aldolase C), while the orange trace shows the reaction of an AldC- cell. The dendrites of the AldC+ cell are present in a microzone called 5+, and the dendrites from the AldC- cell are localized in the 5- microzone. (C) This graph indicates the relative activity of two groups of cells: an AldC- microzone (5a-; blue trace) in the medial Crus II, and the lateral Purkinje cell dendrites, which are similar across several microzones including 7+, 6-, 6+, 5- (gray trace). The activity of the cells is tracked during the reward delivery (blue shaded region) and post-reward intervals, where the difference in activity appears.

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