TY - JOUR TI - Recurrent circuitry is required to stabilize piriform cortex odor representations across brain states AU - Bolding, Kevin A AU - Nagappan, Shivathmihai AU - Han, Bao-Xia AU - Wang, Fan AU - Franks, Kevin M A2 - Liberles, Stephen A2 - Colgin, Laura L VL - 9 PY - 2020 DA - 2020/07/14 SP - e53125 C1 - eLife 2020;9:e53125 DO - 10.7554/eLife.53125 UR - https://doi.org/10.7554/eLife.53125 AB - Pattern completion, or the ability to retrieve stable neural activity patterns from noisy or partial cues, is a fundamental feature of memory. Theoretical studies indicate that recurrently connected auto-associative or discrete attractor networks can perform this process. Although pattern completion and attractor dynamics have been observed in various recurrent neural circuits, the role recurrent circuitry plays in implementing these processes remains unclear. In recordings from head-fixed mice, we found that odor responses in olfactory bulb degrade under ketamine/xylazine anesthesia while responses immediately downstream, in piriform cortex, remain robust. Recurrent connections are required to stabilize cortical odor representations across states. Moreover, piriform odor representations exhibit attractor dynamics, both within and across trials, and these are also abolished when recurrent circuitry is eliminated. Here, we present converging evidence that recurrently-connected piriform populations stabilize sensory representations in response to degraded inputs, consistent with an auto-associative function for piriform cortex supported by recurrent circuitry. KW - olfaction KW - cortical circuits KW - pattern completion JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -