TY - JOUR TI - Conservation and divergence of related neuronal lineages in the Drosophila central brain AU - Lee, Ying-Jou AU - Yang, Ching-Po AU - Miyares, Rosa L AU - Huang, Yu-Fen AU - He, Yisheng AU - Ren, Qingzhong AU - Chen, Hui-Min AU - Kawase, Takashi AU - Ito, Masayoshi AU - Otsuna, Hideo AU - Sugino, Ken AU - Aso, Yoshi AU - Ito, Kei AU - Lee, Tzumin A2 - Desplan, Claude A2 - VijayRaghavan, K VL - 9 PY - 2020 DA - 2020/04/07 SP - e53518 C1 - eLife 2020;9:e53518 DO - 10.7554/eLife.53518 UR - https://doi.org/10.7554/eLife.53518 AB - Wiring a complex brain requires many neurons with intricate cell specificity, generated by a limited number of neural stem cells. Drosophila central brain lineages are a predetermined series of neurons, born in a specific order. To understand how lineage identity translates to neuron morphology, we mapped 18 Drosophila central brain lineages. While we found large aggregate differences between lineages, we also discovered shared patterns of morphological diversification. Lineage identity plus Notch-mediated sister fate govern primary neuron trajectories, whereas temporal fate diversifies terminal elaborations. Further, morphological neuron types may arise repeatedly, interspersed with other types. Despite the complexity, related lineages produce similar neuron types in comparable temporal patterns. Different stem cells even yield two identical series of dopaminergic neuron types, but with unrelated sister neurons. Together, these phenomena suggest that straightforward rules drive incredible neuronal complexity, and that large changes in morphology can result from relatively simple fating mechanisms. KW - hemilineage KW - temporal fate KW - vnd KW - mushroom body KW - central complex KW - twin-spot MARCM JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -