TY - JOUR TI - Primate homologs of mouse cortico-striatal circuits AU - Balsters, Joshua Henk AU - Zerbi, Valerio AU - Sallet, Jerome AU - Wenderoth, Nicole AU - Mars, Rogier B A2 - Wassum, Kate M A2 - Kahnt, Thorsten A2 - Laubach, Mark A2 - White, Samantha VL - 9 PY - 2020 DA - 2020/04/16 SP - e53680 C1 - eLife 2020;9:e53680 DO - 10.7554/eLife.53680 UR - https://doi.org/10.7554/eLife.53680 AB - With the increasing necessity of animal models in biomedical research, there is a vital need to harmonise findings across species by establishing similarities and differences in rodent and primate neuroanatomy. Using connectivity fingerprint matching, we compared cortico-striatal circuits across humans, non-human primates, and mice using resting-state fMRI data in all species. Our results suggest that the connectivity patterns for the nucleus accumbens and cortico-striatal motor circuits (posterior/lateral putamen) were conserved across species, making them reliable targets for cross-species comparisons. However, a large number of human and macaque striatal voxels were not matched to any mouse cortico-striatal circuit (mouse->human: 85% unassigned; mouse->macaque 69% unassigned; macaque->human; 31% unassigned). These unassigned voxels were localised to the caudate nucleus and anterior putamen, overlapping with executive function and social/language regions of the striatum and connected to prefrontal-projecting cerebellar lobules and anterior prefrontal cortex, forming circuits that seem to be unique for non-human primates and humans. KW - connectivity KW - fMRI KW - striatum KW - connectivity fingeprint matching KW - comparative anatomy JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -