TY - JOUR TI - Cancer systems immunology AU - Reticker-Flynn, Nathan E AU - Engleman, Edgar G A2 - Settleman, Jeffrey A2 - Kawakami, Yutaka VL - 9 PY - 2020 DA - 2020/07/13 SP - e53839 C1 - eLife 2020;9:e53839 DO - 10.7554/eLife.53839 UR - https://doi.org/10.7554/eLife.53839 AB - Tumor immunology is undergoing a renaissance due to the recent profound clinical successes of tumor immunotherapy. These advances have coincided with an exponential growth in the development of –omics technologies. Armed with these technologies and their associated computational and modeling toolsets, systems biologists have turned their attention to tumor immunology in an effort to understand the precise nature and consequences of interactions between tumors and the immune system. Such interactions are inherently multivariate, spanning multiple time and size scales, cell types, and organ systems, rendering systems biology approaches particularly amenable to their interrogation. While in its infancy, the field of ‘Cancer Systems Immunology’ has already influenced our understanding of tumor immunology and immunotherapy. As the field matures, studies will move beyond descriptive characterizations toward functional investigations of the emergent behavior that govern tumor-immune responses. Thus, Cancer Systems Immunology holds incredible promise to advance our ability to fight this disease. KW - systems biology KW - tumor immunology KW - cancer systems biology KW - systems immunology KW - tumor immunotherapy JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -