Finkel et al. have used a combination of techniques to reannotate the genomes of human herpesviruses 6A and 6B. They have identified new open reading frames (268 in human herpesvirus 6A and 216 in human herpesvirus 6B) and corrected the annotation of existing frames (10 in human herpesvirus 6A and 11 in human herpesvirus 6B). The figure shows how an open reading frame called U30, which codes for an important protein in both human herpesvirus 6A and 6B, was reannotated. Data from Ribo-Seq (orange) revealed that the start of the open reading frame was downstream of what was expected based on the previous annotation (black) or cRNA-Seq information (blue), leading to a new, more accurate annotation for this sequence (green).