TY - JOUR TI - Anatomy of nerve fiber bundles at micrometer-resolution in the vervet monkey visual system AU - Takemura, Hiromasa AU - Palomero-Gallagher, Nicola AU - Axer, Markus AU - Gräßel, David AU - Jorgensen, Matthew J AU - Woods, Roger AU - Zilles, Karl A2 - Verstynen, Timothy A2 - Behrens, Timothy E A2 - Verstynen, Timothy VL - 9 PY - 2020 DA - 2020/08/26 SP - e55444 C1 - eLife 2020;9:e55444 DO - 10.7554/eLife.55444 UR - https://doi.org/10.7554/eLife.55444 AB - Although the primate visual system has been extensively studied, detailed spatial organization of white matter fiber tracts carrying visual information between areas has not been fully established. This is mainly due to the large gap between tracer studies and diffusion-weighted MRI studies, which focus on specific axonal connections and macroscale organization of fiber tracts, respectively. Here we used 3D polarization light imaging (3D-PLI), which enables direct visualization of fiber tracts at micrometer resolution, to identify and visualize fiber tracts of the visual system, such as stratum sagittale, inferior longitudinal fascicle, vertical occipital fascicle, tapetum and dorsal occipital bundle in vervet monkey brains. Moreover, 3D-PLI data provide detailed information on cortical projections of these tracts, distinction between neighboring tracts, and novel short-range pathways. This work provides essential information for interpretation of functional and diffusion-weighted MRI data, as well as revision of wiring diagrams based upon observations in the vervet visual system. KW - visual system KW - white matter KW - polarized light imaging KW - fiber tracts JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -