TY - JOUR TI - Temperature compensation in a small rhythmic circuit AU - Alonso, Leandro M AU - Marder, Eve A2 - Skinner, Frances K A2 - Westbrook, Gary L A2 - Nadim, Farzan A2 - Guet-McCreight, Alexandre VL - 9 PY - 2020 DA - 2020/06/02 SP - e55470 C1 - eLife 2020;9:e55470 DO - 10.7554/eLife.55470 UR - https://doi.org/10.7554/eLife.55470 AB - Temperature affects the conductances and kinetics of the ionic channels that underlie neuronal activity. Each membrane conductance has a different characteristic temperature sensitivity, which raises the question of how neurons and neuronal circuits can operate robustly over wide temperature ranges. To address this, we employed computational models of the pyloric network of crabs and lobsters. We produced multiple different models that exhibit a triphasic pyloric rhythm over a range of temperatures and explored the dynamics of their currents and how they change with temperature. Temperature can produce smooth changes in the relative contributions of the currents to neural activity so that neurons and networks undergo graceful transitions in the mechanisms that give rise to their activity patterns. Moreover, responses of the models to deletions of a current can be different at high and low temperatures, indicating that even a well-defined genetic or pharmacological manipulation may produce qualitatively distinct effects depending on the temperature. KW - neuronal oscillators KW - ion channels KW - temperature KW - Q10 JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -