TY - JOUR TI - A taxonomy of seizure dynamotypes AU - Saggio, Maria Luisa AU - Crisp, Dakota AU - Scott, Jared M AU - Karoly, Philippa AU - Kuhlmann, Levin AU - Nakatani, Mitsuyoshi AU - Murai, Tomohiko AU - Dümpelmann, Matthias AU - Schulze-Bonhage, Andreas AU - Ikeda, Akio AU - Cook, Mark AU - Gliske, Stephen V AU - Lin, Jack AU - Bernard, Christophe AU - Jirsa, Viktor AU - Stacey, William C A2 - Skinner, Frances K A2 - Frank, Michael J A2 - Van Drongelen, Wim A2 - Valiante, Taufik A VL - 9 PY - 2020 DA - 2020/07/21 SP - e55632 C1 - eLife 2020;9:e55632 DO - 10.7554/eLife.55632 UR - https://doi.org/10.7554/eLife.55632 AB - Seizures are a disruption of normal brain activity present across a vast range of species and conditions. We introduce an organizing principle that leads to the first objective Taxonomy of Seizure Dynamics (TSD) based on bifurcation theory. The ‘dynamotype’ of a seizure is the dynamic composition that defines its observable characteristics, including how it starts, evolves and ends. Analyzing over 2000 focal-onset seizures from multiple centers, we find evidence of all 16 dynamotypes predicted in TSD. We demonstrate that patients’ dynamotypes evolve during their lifetime and display complex but systematic variations including hierarchy (certain types are more common), non-bijectivity (a patient may display multiple types) and pairing preference (multiple types may occur during one seizure). TSD provides a way to stratify patients in complement to present clinical classifications, a language to describe the most critical features of seizure dynamics, and a framework to guide future research focused on dynamical properties. KW - epilepsy KW - seizure KW - dynamics KW - bifurcation KW - intracranial EEG JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -