1. Computational and Systems Biology
  2. Neuroscience

A connectome and analysis of the adult Drosophila central brain

  1. Louis K Scheffer  Is a corresponding author
  2. C Shan Xu
  3. Michal Januszewski
  4. Zhiyuan Lu
  5. Shin-ya Takemura
  6. Kenneth J Hayworth
  7. Gary B Huang
  8. Kazunori Shinomiya
  9. Jeremy Maitlin-Shepard
  10. Stuart Berg
  11. Jody Clements
  12. Philip M Hubbard
  13. William T Katz
  14. Lowell Umayam
  15. Ting Zhao
  16. David Ackerman
  17. Tim Blakely
  18. John Bogovic
  19. Tom Dolafi
  20. Dagmar Kainmueller
  21. Takashi Kawase
  22. Khaled A Khairy
  23. Laramie Leavitt
  24. Peter H Li
  25. Larry Lindsey
  26. Nicole Neubarth
  27. Donald J Olbris
  28. Hideo Otsuna
  29. Eric T Trautman
  30. Masayoshi Ito
  31. Alexander S Bates
  32. Jens Goldammer
  33. Tanya Wolff
  34. Robert Svirskas
  35. Philipp Schlegel
  36. Erika Neace
  37. Christopher J Knecht
  38. Chelsea X Alvarado
  39. Dennis A Bailey
  40. Samantha Ballinger
  41. Jolanta A Borycz
  42. Brandon S Canino
  43. Natasha Cheatham
  44. Michael Cook
  45. Marisa Dreher
  46. Octave Duclos
  47. Bryon Eubanks
  48. Kelli Fairbanks
  49. Samantha Finley
  50. Nora Forknall
  51. Audrey Francis
  52. Gary Patrick Hopkins
  53. Emily M Joyce
  54. SungJin Kim
  55. Nicole A Kirk
  56. Julie Kovalyak
  57. Shirley Lauchie
  58. Alanna Lohff
  59. Charli Maldonado
  60. Emily A Manley
  61. Sari McLin
  62. Caroline Mooney
  63. Miatta Ndama
  64. Omotara Ogundeyi
  65. Nneoma Okeoma
  66. Christopher Ordish
  67. Nicholas Padilla
  68. Christopher M Patrick
  69. Tyler Paterson
  70. Elliott E Phillips
  71. Emily M Phillips
  72. Neha Rampally
  73. Caitlin Ribeiro
  74. Madelaine K Robertson
  75. Jon Thomson Rymer
  76. Sean M Ryan
  77. Megan Sammons
  78. Anne K Scott
  79. Ashley L Scott
  80. Aya Shinomiya
  81. Claire Smith
  82. Kelsey Smith
  83. Natalie L Smith
  84. Margaret A Sobeski
  85. Alia Suleiman
  86. Jackie Swift
  87. Satoko Takemura
  88. Iris Talebi
  89. Dorota Tarnogorska
  90. Emily Tenshaw
  91. Temour Tokhi
  92. John J Walsh
  93. Tansy Yang
  94. Jane Anne Horne
  95. Feng Li
  96. Ruchi Parekh
  97. Patricia K Rivlin
  98. Vivek Jayaraman
  99. Marta Costa
  100. Gregory SXE Jefferis
  101. Kei Ito
  102. Stephan Saalfeld
  103. Reed George
  104. Ian Meinertzhagen
  105. Gerald M Rubin
  106. Harald F Hess
  107. Viren Jain
  108. Stephen M Plaza
  1. Janelia Research Campus, Howard Hughes Medical Institute, United States
  2. Google LLC, Switzerland
  3. Google LLC, United States
  4. MRC Laboratory of Molecular Biology, United Kingdom
  5. Dalhousie University, Canada
  6. University of Cambridge, United Kingdom
  7. University of Cologne, Germany
https://doi.org/10.7554/eLife.57443
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Cite this article
  1. Louis K Scheffer
  2. C Shan Xu
  3. Michal Januszewski
  4. Zhiyuan Lu
  5. Shin-ya Takemura
  6. Kenneth J Hayworth
  7. Gary B Huang
  8. Kazunori Shinomiya
  9. Jeremy Maitlin-Shepard
  10. Stuart Berg
  11. Jody Clements
  12. Philip M Hubbard
  13. William T Katz
  14. Lowell Umayam
  15. Ting Zhao
  16. David Ackerman
  17. Tim Blakely
  18. John Bogovic
  19. Tom Dolafi
  20. Dagmar Kainmueller
  21. Takashi Kawase
  22. Khaled A Khairy
  23. Laramie Leavitt
  24. Peter H Li
  25. Larry Lindsey
  26. Nicole Neubarth
  27. Donald J Olbris
  28. Hideo Otsuna
  29. Eric T Trautman
  30. Masayoshi Ito
  31. Alexander S Bates
  32. Jens Goldammer
  33. Tanya Wolff
  34. Robert Svirskas
  35. Philipp Schlegel
  36. Erika Neace
  37. Christopher J Knecht
  38. Chelsea X Alvarado
  39. Dennis A Bailey
  40. Samantha Ballinger
  41. Jolanta A Borycz
  42. Brandon S Canino
  43. Natasha Cheatham
  44. Michael Cook
  45. Marisa Dreher
  46. Octave Duclos
  47. Bryon Eubanks
  48. Kelli Fairbanks
  49. Samantha Finley
  50. Nora Forknall
  51. Audrey Francis
  52. Gary Patrick Hopkins
  53. Emily M Joyce
  54. SungJin Kim
  55. Nicole A Kirk
  56. Julie Kovalyak
  57. Shirley Lauchie
  58. Alanna Lohff
  59. Charli Maldonado
  60. Emily A Manley
  61. Sari McLin
  62. Caroline Mooney
  63. Miatta Ndama
  64. Omotara Ogundeyi
  65. Nneoma Okeoma
  66. Christopher Ordish
  67. Nicholas Padilla
  68. Christopher M Patrick
  69. Tyler Paterson
  70. Elliott E Phillips
  71. Emily M Phillips
  72. Neha Rampally
  73. Caitlin Ribeiro
  74. Madelaine K Robertson
  75. Jon Thomson Rymer
  76. Sean M Ryan
  77. Megan Sammons
  78. Anne K Scott
  79. Ashley L Scott
  80. Aya Shinomiya
  81. Claire Smith
  82. Kelsey Smith
  83. Natalie L Smith
  84. Margaret A Sobeski
  85. Alia Suleiman
  86. Jackie Swift
  87. Satoko Takemura
  88. Iris Talebi
  89. Dorota Tarnogorska
  90. Emily Tenshaw
  91. Temour Tokhi
  92. John J Walsh
  93. Tansy Yang
  94. Jane Anne Horne
  95. Feng Li
  96. Ruchi Parekh
  97. Patricia K Rivlin
  98. Vivek Jayaraman
  99. Marta Costa
  100. Gregory SXE Jefferis
  101. Kei Ito
  102. Stephan Saalfeld
  103. Reed George
  104. Ian Meinertzhagen
  105. Gerald M Rubin
  106. Harald F Hess
  107. Viren Jain
  108. Stephen M Plaza
(2020)
A connectome and analysis of the adult Drosophila central brain
eLife 9:e57443.
https://doi.org/10.7554/eLife.57443
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  3. Download .RIS

Abstract

The neural circuits responsible for animal behavior remain largely unknown. We summarize new methods and present the circuitry of a large fraction of the brain of the fruit fly Drosophila melanogaster. Improved methods include new procedures to prepare, image, align, segment, find synapses in, and proofread such large data sets. We define cell types, refine computational compartments, and provide an exhaustive atlas of cell examples and types, many of them novel. We provide detailed circuits consisting of neurons and their chemical synapses for most of the central brain. We make the data public and simplify access, reducing the effort needed to answer circuit questions, and provide procedures linking the neurons defined by our analysis with genetic reagents. Biologically, we examine distributions of connection strengths, neural motifs on different scales, electrical consequences of compartmentalization, and evidence that maximizing packing density is an important criterion in the evolution of the fly's brain.

Data availability

There is no institutional resource for hosting connectome data. Therefore we host it ourselves on a publicly accessible web site, https://neuprint.janelia.org, also accessible via https://doi.org/10.25378/janelia.11676099.v2 . We commit to keeping this available for at least 10 years, and provide procedures where users can copy any or all of it to their own computer. Login is via any Google account; users who wish to remain anonymous can create a separate account for access purposes only.

Article and author information

Author details

  1. Louis K Scheffer

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    For correspondence
    schefferl@janelia.hhmi.org
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-3289-6564

  2. C Shan Xu

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-8564-7836

  3. Michal Januszewski

    Google Research, Google LLC, Zurich, Switzerland
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-3480-2744

  4. Zhiyuan Lu

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-4128-9774

  5. Shin-ya Takemura

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0003-2400-6426

  6. Kenneth J Hayworth

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.

  7. Gary B Huang

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-9606-3510

  8. Kazunori Shinomiya

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0003-0262-6421

  9. Jeremy Maitlin-Shepard

    Google Research, Google LLC, Mountain View, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0001-8453-7961

  10. Stuart Berg

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.

  11. Jody Clements

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.

  12. Philip M Hubbard

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-6746-5035

  13. William T Katz

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-9417-6212

  14. Lowell Umayam

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.

  15. Ting Zhao

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.

  16. David Ackerman

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0003-0172-6594

  17. Tim Blakely

    Google Research, Google LLC, Mountain View, CA, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0003-0995-5471

  18. John Bogovic

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-4829-9457

  19. Tom Dolafi

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.

  20. Dagmar Kainmueller

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-9830-2415

  21. Takashi Kawase

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.

  22. Khaled A Khairy

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-9274-5928

  23. Laramie Leavitt

    Google Research, Google LLC, Mountain View, CA, United States
    Competing interests
    The authors declare that no competing interests exist.

  24. Peter H Li

    Google Research, Google LLC, Mountain View, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0001-6193-4454

  25. Larry Lindsey

    Google Research, Google LLC, MOuntain View, CA, United States
    Competing interests
    The authors declare that no competing interests exist.

  26. Nicole Neubarth

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.

  27. Donald J Olbris

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.

  28. Hideo Otsuna

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.

  29. Eric T Trautman

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0001-8588-0569

  30. Masayoshi Ito

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.

  31. Alexander S Bates

    Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-1195-0445

  32. Jens Goldammer

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-5623-8339

  33. Tanya Wolff

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-8681-1749

  34. Robert Svirskas

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0001-8374-6008

  35. Philipp Schlegel

    Division of Neurobiology, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-5633-1314

  36. Erika Neace

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.

  37. Christopher J Knecht

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-5663-5967

  38. Chelsea X Alvarado

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-5973-7512

  39. Dennis A Bailey

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-4675-8373

  40. Samantha Ballinger

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.

  41. Jolanta A Borycz

    Psychology and Neuroscience, Dalhousie University, Halifax, Canada
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-4402-9230

  42. Brandon S Canino

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-8454-865X

  43. Natasha Cheatham

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.

  44. Michael Cook

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-7892-6845

  45. Marisa Dreher

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-0041-9229

  46. Octave Duclos

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, United States
    Competing interests
    The authors declare that no competing interests exist.

  47. Bryon Eubanks

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-9288-2009

  48. Kelli Fairbanks

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-6601-4830

  49. Samantha Finley

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-8086-206X

  50. Nora Forknall

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0003-2139-7599

  51. Audrey Francis

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0003-1974-7174

  52. Gary Patrick Hopkins

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, United States
    Competing interests
    The authors declare that no competing interests exist.

  53. Emily M Joyce

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0001-5794-6321

  54. SungJin Kim

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, United States
    Competing interests
    The authors declare that no competing interests exist.

  55. Nicole A Kirk

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, United States
    Competing interests
    The authors declare that no competing interests exist.

  56. Julie Kovalyak

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0001-7864-7734

  57. Shirley Lauchie

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0001-8223-9522

  58. Alanna Lohff

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-1242-1836

  59. Charli Maldonado

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, United States
    Competing interests
    The authors declare that no competing interests exist.

  60. Emily A Manley

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, United States
    Competing interests
    The authors declare that no competing interests exist.

  61. Sari McLin

    Department of Psychology and Neuroscience, Dalhousie University, Halifax, Canada
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-9120-1136

  62. Caroline Mooney

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, United States
    Competing interests
    The authors declare that no competing interests exist.

  63. Miatta Ndama

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, United States
    Competing interests
    The authors declare that no competing interests exist.

  64. Omotara Ogundeyi

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.

  65. Nneoma Okeoma

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, United States
    Competing interests
    The authors declare that no competing interests exist.

  66. Christopher Ordish

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.

  67. Nicholas Padilla

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, United States
    Competing interests
    The authors declare that no competing interests exist.

  68. Christopher M Patrick

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0001-8830-1892

  69. Tyler Paterson

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, United States
    Competing interests
    The authors declare that no competing interests exist.

  70. Elliott E Phillips

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-4918-2058

  71. Emily M Phillips

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0001-7615-301X

  72. Neha Rampally

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, United States
    Competing interests
    The authors declare that no competing interests exist.

  73. Caitlin Ribeiro

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, United States
    Competing interests
    The authors declare that no competing interests exist.

  74. Madelaine K Robertson

    Psychology and Neuroscience, Dalhousie University, Halifax, Canada
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-1764-0245

  75. Jon Thomson Rymer

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-4271-6774

  76. Sean M Ryan

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-8879-6108

  77. Megan Sammons

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0003-4516-5928

  78. Anne K Scott

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, United States
    Competing interests
    The authors declare that no competing interests exist.

  79. Ashley L Scott

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, United States
    Competing interests
    The authors declare that no competing interests exist.

  80. Aya Shinomiya

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-6358-9567

  81. Claire Smith

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.

  82. Kelsey Smith

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, United States
    Competing interests
    The authors declare that no competing interests exist.

  83. Natalie L Smith

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-8271-9873

  84. Margaret A Sobeski

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, United States
    Competing interests
    The authors declare that no competing interests exist.

  85. Alia Suleiman

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, United States
    Competing interests
    The authors declare that no competing interests exist.

  86. Jackie Swift

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0003-1321-8183

  87. Satoko Takemura

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-2863-0050

  88. Iris Talebi

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-0173-8053

  89. Dorota Tarnogorska

    Psychology and Neuroscience, Dalhousie University, Halifax, Canada
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-7063-6165

  90. Emily Tenshaw

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, United States
    Competing interests
    The authors declare that no competing interests exist.

  91. Temour Tokhi

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, United States
    Competing interests
    The authors declare that no competing interests exist.

  92. John J Walsh

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-7176-4708

  93. Tansy Yang

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0003-1131-0410

  94. Jane Anne Horne

    Department of Psychology and Neuroscience, Dalhousie University, Halifax, Canada
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0001-9673-2692

  95. Feng Li

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.

  96. Ruchi Parekh

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-8060-2807

  97. Patricia K Rivlin

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.

  98. Vivek Jayaraman

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0003-3680-7378

  99. Marta Costa

    Department of Zoology, University of Cambridge, Cambridge, United Kingdom
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0001-5948-3092

  100. Gregory SXE Jefferis

    Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-0587-9355

  101. Kei Ito

    Institute of Zoology, University of Cologne, Cologne, Germany
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-7274-5533

  102. Stephan Saalfeld

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-4106-1761

  103. Reed George

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, United States
    Competing interests
    The authors declare that no competing interests exist.

  104. Ian Meinertzhagen

    Department of Psychology and Neuroscience, Dalhousie University, Halifax, Canada
    Competing interests
    The authors declare that no competing interests exist.

  105. Gerald M Rubin

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0001-8762-8703

  106. Harald F Hess

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0003-3000-1533

  107. Viren Jain

    Google research, Google LLC, Mountain View, CA, United States
    Competing interests
    The authors declare that no competing interests exist.

  108. Stephen M Plaza

    Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0001-7425-8555

Funding

Howard Hughes Medical Institute (Internal funding)

  • Louis K Scheffer
  • C Shan Xu
  • Zhiyuan Lu
  • Shin-ya Takemura
  • Kenneth J Hayworth
  • Gary B Huang
  • Kazunori Shinomiya
  • Stuart Berg
  • Jody Clements
  • Philip M Hubbard
  • William T Katz
  • Lowell Umayam
  • Ting Zhao
  • David Ackerman
  • John Bogovic
  • Tom Dolafi
  • Dagmar Kainmueller
  • Khaled A Khairy
  • Nicole Neubarth
  • Donald J Olbris
  • Hideo Otsuna
  • Eric T Trautman
  • Masayoshi Ito
  • Jens Goldammer
  • Tanya Wolff
  • Robert Svirskas
  • Erika Neace
  • Christopher J Knecht
  • Chelsea X Alvarado
  • Dennis A Bailey
  • Samantha Ballinger
  • Jolanta A Borycz
  • Brandon S Canino
  • Natasha Cheatham
  • Michael Cook
  • Marisa Dreher
  • Octave Duclos
  • Bryon Eubanks
  • Kelli Fairbanks
  • Samantha Finley
  • Nora Forknall
  • Audrey Francis
  • Gary Patrick Hopkins
  • Emily M Joyce
  • SungJin Kim
  • Nicole A Kirk
  • Julie Kovalyak
  • Shirley Lauchie
  • Alanna Lohff
  • Charli Maldonado
  • Emily A Manley
  • Sari McLin
  • Caroline Mooney
  • Miatta Ndama
  • Omotara Ogundeyi
  • Nneoma Okeoma
  • Christopher Ordish
  • Nicholas Padilla
  • Christopher M Patrick
  • Tyler Paterson
  • Elliott E Phillips
  • Emily M Phillips
  • Neha Rampally
  • Caitlin Ribeiro
  • Madelaine K Robertson
  • Jon Thomson Rymer
  • Sean M Ryan
  • Megan Sammons
  • Anne K Scott
  • Ashley L Scott
  • Aya Shinomiya
  • Claire Smith
  • Kelsey Smith
  • Natalie L Smith
  • Margaret A Sobeski
  • Alia Suleiman
  • Jackie Swift
  • Satoko Takemura
  • Iris Talebi
  • Dorota Tarnogorska
  • Emily Tenshaw
  • Temour Tokhi
  • John J Walsh
  • Tansy Yang
  • Jane Anne Horne
  • Ruchi Parekh
  • Patricia K Rivlin
  • Vivek Jayaraman
  • Kei Ito
  • Stephan Saalfeld
  • Reed George
  • Ian Meinertzhagen
  • Gerald M Rubin
  • Harald F Hess
  • Stephen M Plaza

Google LLC (Internal funding)

  • Michal Januszewski
  • Jeremy Maitlin-Shepard
  • Tim Blakely
  • Laramie Leavitt
  • Peter H Li
  • Larry Lindsey
  • Viren Jain

Wellcome (203261/Z/16/Z)

  • Philipp Schlegel
  • Feng Li

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Copyright

© 2020, Scheffer et al.

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

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  1. Louis K Scheffer
  2. C Shan Xu
  3. Michal Januszewski
  4. Zhiyuan Lu
  5. Shin-ya Takemura
  6. Kenneth J Hayworth
  7. Gary B Huang
  8. Kazunori Shinomiya
  9. Jeremy Maitlin-Shepard
  10. Stuart Berg
  11. Jody Clements
  12. Philip M Hubbard
  13. William T Katz
  14. Lowell Umayam
  15. Ting Zhao
  16. David Ackerman
  17. Tim Blakely
  18. John Bogovic
  19. Tom Dolafi
  20. Dagmar Kainmueller
  21. Takashi Kawase
  22. Khaled A Khairy
  23. Laramie Leavitt
  24. Peter H Li
  25. Larry Lindsey
  26. Nicole Neubarth
  27. Donald J Olbris
  28. Hideo Otsuna
  29. Eric T Trautman
  30. Masayoshi Ito
  31. Alexander S Bates
  32. Jens Goldammer
  33. Tanya Wolff
  34. Robert Svirskas
  35. Philipp Schlegel
  36. Erika Neace
  37. Christopher J Knecht
  38. Chelsea X Alvarado
  39. Dennis A Bailey
  40. Samantha Ballinger
  41. Jolanta A Borycz
  42. Brandon S Canino
  43. Natasha Cheatham
  44. Michael Cook
  45. Marisa Dreher
  46. Octave Duclos
  47. Bryon Eubanks
  48. Kelli Fairbanks
  49. Samantha Finley
  50. Nora Forknall
  51. Audrey Francis
  52. Gary Patrick Hopkins
  53. Emily M Joyce
  54. SungJin Kim
  55. Nicole A Kirk
  56. Julie Kovalyak
  57. Shirley Lauchie
  58. Alanna Lohff
  59. Charli Maldonado
  60. Emily A Manley
  61. Sari McLin
  62. Caroline Mooney
  63. Miatta Ndama
  64. Omotara Ogundeyi
  65. Nneoma Okeoma
  66. Christopher Ordish
  67. Nicholas Padilla
  68. Christopher M Patrick
  69. Tyler Paterson
  70. Elliott E Phillips
  71. Emily M Phillips
  72. Neha Rampally
  73. Caitlin Ribeiro
  74. Madelaine K Robertson
  75. Jon Thomson Rymer
  76. Sean M Ryan
  77. Megan Sammons
  78. Anne K Scott
  79. Ashley L Scott
  80. Aya Shinomiya
  81. Claire Smith
  82. Kelsey Smith
  83. Natalie L Smith
  84. Margaret A Sobeski
  85. Alia Suleiman
  86. Jackie Swift
  87. Satoko Takemura
  88. Iris Talebi
  89. Dorota Tarnogorska
  90. Emily Tenshaw
  91. Temour Tokhi
  92. John J Walsh
  93. Tansy Yang
  94. Jane Anne Horne
  95. Feng Li
  96. Ruchi Parekh
  97. Patricia K Rivlin
  98. Vivek Jayaraman
  99. Marta Costa
  100. Gregory SXE Jefferis
  101. Kei Ito
  102. Stephan Saalfeld
  103. Reed George
  104. Ian Meinertzhagen
  105. Gerald M Rubin
  106. Harald F Hess
  107. Viren Jain
  108. Stephen M Plaza
(2020)
A connectome and analysis of the adult Drosophila central brain
eLife 9:e57443.
https://doi.org/10.7554/eLife.57443

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