TY - JOUR TI - Activity-dependent tuning of intrinsic excitability in mouse and human neurogliaform cells AU - Chittajallu, Ramesh AU - Auville, Kurt AU - Mahadevan, Vivek AU - Lai, Mandy AU - Hunt, Steven AU - Calvigioni, Daniela AU - Pelkey, Kenneth A AU - Zaghloul, Kareem A AU - McBain, Chris J A2 - Westbrook, Gary L A2 - Overstreet-Wadiche, Linda A2 - Overstreet-Wadiche, Linda A2 - Szabadics, János A2 - Letzkus, Johannes J VL - 9 PY - 2020 DA - 2020/06/04 SP - e57571 C1 - eLife 2020;9:e57571 DO - 10.7554/eLife.57571 UR - https://doi.org/10.7554/eLife.57571 AB - The ability to modulate the efficacy of synaptic communication between neurons constitutes an essential property critical for normal brain function. Animal models have proved invaluable in revealing a wealth of diverse cellular mechanisms underlying varied plasticity modes. However, to what extent these processes are mirrored in humans is largely uncharted thus questioning their relevance in human circuit function. In this study, we focus on neurogliaform cells, that possess specialized physiological features enabling them to impart a widespread inhibitory influence on neural activity. We demonstrate that this prominent neuronal subtype, embedded in both mouse and human neural circuits, undergo remarkably similar activity-dependent modulation manifesting as epochs of enhanced intrinsic excitability. In principle, these evolutionary conserved plasticity routes likely tune the extent of neurogliaform cell mediated inhibition thus constituting canonical circuit mechanisms underlying human cognitive processing and behavior. KW - neurogliaform cell KW - intrinsic excitablity KW - plasticity KW - interneuron JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -