TY - JOUR TI - Long-term potentiation is independent of the C-tail of the GluA1 AMPA receptor subunit AU - Díaz-Alonso, Javier AU - Morishita, Wade AU - Incontro, Salvatore AU - Simms, Jeffrey AU - Holtzman, Julia AU - Gill, Michael AU - Mucke, Lennart AU - Malenka, Robert C AU - Nicoll, Roger A A2 - Overstreet-Wadiche, Linda A2 - Aldrich, Richard W A2 - Overstreet-Wadiche, Linda VL - 9 PY - 2020 DA - 2020/08/24 SP - e58042 C1 - eLife 2020;9:e58042 DO - 10.7554/eLife.58042 UR - https://doi.org/10.7554/eLife.58042 AB - We tested the proposal that the C-terminal domain (CTD) of the AMPAR subunit GluA1 is required for LTP. We found that a knock-in mouse lacking the CTD of GluA1 expresses normal LTP and spatial memory, assayed by the Morris water maze. Our results support a model in which LTP generates synaptic slots, which capture passively diffusing AMPARs. KW - long-term potentiation KW - synaptic plasticity KW - AMPA receptor KW - spatial learning KW - hippocampus KW - memory formation JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -