TY - JOUR TI - Long non-coding RNAs in regulation of adipogenesis and adipose tissue function AU - Squillaro, Tiziana AU - Peluso, Gianfranco AU - Galderisi, Umberto AU - Di Bernardo, Giovanni A2 - Rosen, Clifford J VL - 9 PY - 2020 DA - 2020/07/30 SP - e59053 C1 - eLife 2020;9:e59053 DO - 10.7554/eLife.59053 UR - https://doi.org/10.7554/eLife.59053 AB - Complex interaction between genetics, epigenetics, environment, and nutrition affect the physiological activities of adipose tissues and their dysfunctions, which lead to several metabolic diseases including obesity or type 2 diabetes. Here, adipogenesis appears to be a process characterized by an intricate network that involves many transcription factors and long noncoding RNAs (lncRNAs) that regulate gene expression. LncRNAs are being investigated to determine their contribution to adipose tissue development and function. LncRNAs possess multiple cellular functions, and they regulate chromatin remodeling, along with transcriptional and post-transcriptional events; in this way, they affect gene expression. New investigations have demonstrated the pivotal role of these molecules in modulating white and brown/beige adipogenic tissue development and activity. This review aims to provide an update on the role of lncRNAs in adipogenesis and adipose tissue function to promote identification of new drug targets for treating obesity and related metabolic diseases. KW - lncRNA KW - adipogenesis KW - obesity KW - brown fat KW - white fat JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -