TY - JOUR TI - Frontal eye field and caudate neurons make different contributions to reward-biased perceptual decisions AU - Fan, Yunshu AU - Gold, Joshua I AU - Ding, Long A2 - Lee, Daeyeol A2 - Frank, Michael J A2 - Chandrasekaran, Chandramouli A2 - Ditterich, Jochen VL - 9 PY - 2020 DA - 2020/11/27 SP - e60535 C1 - eLife 2020;9:e60535 DO - 10.7554/eLife.60535 UR - https://doi.org/10.7554/eLife.60535 AB - Many decisions require trade-offs between sensory evidence and internal preferences. Potential neural substrates include the frontal eye field (FEF) and caudate nucleus, but their distinct roles are not understood. Previously we showed that monkeys’ decisions on a direction-discrimination task with asymmetric rewards reflected a biased accumulate-to-bound decision process (Fan et al., 2018) that was affected by caudate microstimulation (Doi et al., 2020). Here we compared single-neuron activity in FEF and caudate to each other and to accumulate-to-bound model predictions derived from behavior. Task-dependent neural modulations were similar in both regions. However, choice-selective neurons in FEF, but not caudate, encoded behaviorally derived biases in the accumulation process. Baseline activity in both regions was sensitive to reward context, but this sensitivity was not reliably associated with behavioral biases. These results imply distinct contributions of FEF and caudate neurons to reward-biased decision-making and put experimental constraints on the neural implementation of accumulation-to-bound-like computations. KW - basal ganglia KW - frontal cortex KW - decision-making KW - saccade KW - striatum KW - drift-diffusion model JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -