TY - JOUR TI - Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study AU - Eyre, David W AU - Lumley, Sheila F AU - O'Donnell, Denise AU - Campbell, Mark AU - Sims, Elizabeth AU - Lawson, Elaine AU - Warren, Fiona AU - James, Tim AU - Cox, Stuart AU - Howarth, Alison AU - Doherty, George AU - Hatch, Stephanie B AU - Kavanagh, James AU - Chau, Kevin K AU - Fowler, Philip W AU - Swann, Jeremy AU - Volk, Denis AU - Yang-Turner, Fan AU - Stoesser, Nicole AU - Matthews, Philippa C AU - Dudareva, Maria AU - Davies, Timothy AU - Shaw, Robert H AU - Peto, Leon AU - Downs, Louise O AU - Vogt, Alexander AU - Amini, Ali AU - Young, Bernadette C AU - Drennan, Philip George AU - Mentzer, Alexander J AU - Skelly, Donal T AU - Karpe, Fredrik AU - Neville, Matt J AU - Andersson, Monique AU - Brent, Andrew J AU - Jones, Nicola AU - Martins Ferreira, Lucas AU - Christott, Thomas AU - Marsden, Brian D AU - Hoosdally, Sarah AU - Cornall, Richard AU - Crook, Derrick W AU - Stuart, David I AU - Screaton, Gavin AU - Oxford University Hospitals Staff Testing Group AU - Peto, Timothy EA AU - Holthof, Bruno AU - O'Donnell, Anne-Marie AU - Ebner, Daniel AU - Conlon, Christopher P AU - Jeffery, Katie AU - Walker, Timothy M A2 - Lipsitch, Marc A2 - Davenport, Miles P A2 - Torok, M Estee VL - 9 PY - 2020 DA - 2020/08/21 SP - e60675 C1 - eLife 2020;9:e60675 DO - 10.7554/eLife.60675 UR - https://doi.org/10.7554/eLife.60675 AB - We conducted voluntary Covid-19 testing programmes for symptomatic and asymptomatic staff at a UK teaching hospital using naso-/oro-pharyngeal PCR testing and immunoassays for IgG antibodies. 1128/10,034 (11.2%) staff had evidence of Covid-19 at some time. Using questionnaire data provided on potential risk-factors, staff with a confirmed household contact were at greatest risk (adjusted odds ratio [aOR] 4.82 [95%CI 3.45–6.72]). Higher rates of Covid-19 were seen in staff working in Covid-19-facing areas (22.6% vs. 8.6% elsewhere) (aOR 2.47 [1.99–3.08]). Controlling for Covid-19-facing status, risks were heterogenous across the hospital, with higher rates in acute medicine (1.52 [1.07–2.16]) and sporadic outbreaks in areas with few or no Covid-19 patients. Covid-19 intensive care unit staff were relatively protected (0.44 [0.28–0.69]), likely by a bundle of PPE-related measures. Positive results were more likely in Black (1.66 [1.25–2.21]) and Asian (1.51 [1.28–1.77]) staff, independent of role or working location, and in porters and cleaners (2.06 [1.34–3.15]). KW - Covid-19 KW - SARS-CoV-2 KW - healthcare workers KW - serology KW - risk factors KW - symptoms JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -