Processing of motion-boundary orientation in macaque V2
- Beijing Normal University, China
Abstract
Human and non-human primates are good at identifying an object based on its motion, a task that is believed to be carried out by the ventral visual pathway. However, the neural mechanisms underlying such ability remains unclear. We trained macaque monkeys to do orientation discrimination for motion-boundaries (MB) and recorded neuronal response in area V2 with microelectrode arrays. We found 10.9% of V2 neurons exhibited robust orientation-selectivity to MBs, and their responses correlated with monkeys' orientation-discrimination performances. Furthermore, the responses of V2 direction-selective neurons recorded at the same time showed correlated activity with MB neurons for particular MB stimuli, suggesting that these motion-sensitive neurons made specific functional contributions to MB discrimination tasks. Our findings support the view that V2 plays a critical role in MB analysis and may achieve this through a neural circuit within area V2.
Data availability
Data and codes are available in Mendeley dataset.http://dx.doi.org/10.17632/fjy37kc8pd.3
-
Processing of motion-boundary orientation in macaque V2Mendeley Data, DOI 10.17632/fjy37kc8pd.3.
Article and author information
Author details
Funding
National Natural Science Foundation of China (31530029)
- Haidong D Lu
National Natural Science Foundation of China (31625012)
- Haidong D Lu
National Natural Science Foundation of China (31371111)
- Haidong D Lu
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Ethics
Animal experimentation: Four hemispheres from two adult male macaque monkeys (Macaca mulatta) were used in this study. All procedures were performed in accordance with the National Institutes of Health Guidelines and were approved by the Institutional Animal Care and Use Committee of the Beijing Normal University (protocol number: IACUC(BNU)-NKCNL2013-13).
Copyright
© 2021, Ma et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
Metrics
-
- 933
- views
-
- 135
- downloads
-
- 0
- citations
Views, downloads and citations are aggregated across all versions of this paper published by eLife.
Download links
A two-part list of links to download the article, or parts of the article, in various formats.
Downloads (link to download the article as PDF)
Open citations (links to open the citations from this article in various online reference manager services)
Cite this article (links to download the citations from this article in formats compatible with various reference manager tools)
Processing of motion-boundary orientation in macaque V2
eLife 10:e61317.
https://doi.org/10.7554/eLife.61317
Further reading
-
- Neuroscience
The neural noise hypothesis of dyslexia posits an imbalance between excitatory and inhibitory (E/I) brain activity as an underlying mechanism of reading difficulties. This study provides the first direct test of this hypothesis using both electroencephalography (EEG) power spectrum measures in 120 Polish adolescents and young adults (60 with dyslexia, 60 controls) and glutamate (Glu) and gamma-aminobutyric acid (GABA) concentrations from magnetic resonance spectroscopy (MRS) at 7T MRI scanner in half of the sample. Our results, supported by Bayesian statistics, show no evidence of E/I balance differences between groups, challenging the hypothesis that cortical hyperexcitability underlies dyslexia. These findings suggest that alternative mechanisms must be explored and highlight the need for further research into the E/I balance and its role in neurodevelopmental disorders.
-
- Biochemistry and Chemical Biology
- Neuroscience
The buildup of knot-like RNA structures in brain cells may be the key to understanding how uncontrolled protein aggregation drives Alzheimer’s disease.
