TY - JOUR TI - A self-balancing circuit centered on MoOsm1 kinase governs adaptive responses to host-derived ROS in Magnaporthe oryzae AU - Liu, Xinyu AU - Zhou, Qikun AU - Guo, Ziqian AU - Liu, Peng AU - Shen, Lingbo AU - Chai, Ning AU - Qian, Bin AU - Cai, Yongchao AU - Wang, Wenya AU - Yin, Ziyi AU - Zhang, Haifeng AU - Zheng, Xiaobo AU - Zhang, Zhengguang A2 - Raffaele, Sylvain A2 - Weigel, Detlef VL - 9 PY - 2020 DA - 2020/12/04 SP - e61605 C1 - eLife 2020;9:e61605 DO - 10.7554/eLife.61605 UR - https://doi.org/10.7554/eLife.61605 AB - The production of reactive oxygen species (ROS) is a ubiquitous defense response in plants. Adapted pathogens evolved mechanisms to counteract the deleterious effects of host-derived ROS and promote infection. How plant pathogens regulate this elaborate response against ROS burst remains unclear. Using the rice blast fungus Magnaporthe oryzae, we uncovered a self-balancing circuit controlling response to ROS in planta and virulence. During infection, ROS induces phosphorylation of the high osmolarity glycerol pathway kinase MoOsm1 and its nuclear translocation. There, MoOsm1 phosphorylates transcription factor MoAtf1 and dissociates MoAtf1-MoTup1 complex. This releases MoTup1-mediated transcriptional repression on oxidoreduction-pathway genes and activates the transcription of MoPtp1/2 protein phosphatases. In turn, MoPtp1/2 dephosphorylate MoOsm1, restoring the circuit to its initial state. Balanced interactions among proteins centered on MoOsm1 provide a means to counter host-derived ROS. Our findings thereby reveal new insights into how M. oryzae utilizes a phosphor-regulatory circuitry to face plant immunity during infection. KW - transcription factor KW - M. oryzae KW - pathogenicity KW - phosphorylation KW - reactive oxygen species JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -