TY - JOUR TI - Control of feeding by Piezo-mediated gut mechanosensation in Drosophila AU - Min, Soohong AU - Oh, Yangkyun AU - Verma, Pushpa AU - Whitehead, Samuel C AU - Yapici, Nilay AU - Van Vactor, David AU - Suh, Greg SB AU - Liberles, Stephen A2 - Desplan, Claude A2 - Sengupta, Piali VL - 10 PY - 2021 DA - 2021/02/18 SP - e63049 C1 - eLife 2021;10:e63049 DO - 10.7554/eLife.63049 UR - https://doi.org/10.7554/eLife.63049 AB - Across animal species, meals are terminated after ingestion of large food volumes, yet underlying mechanosensory receptors have so far remained elusive. Here, we identify an essential role for Drosophila Piezo in volume-based control of meal size. We discover a rare population of fly neurons that express Piezo, innervate the anterior gut and crop (a food reservoir organ), and respond to tissue distension in a Piezo-dependent manner. Activating Piezo neurons decreases appetite, while Piezo knockout and Piezo neuron silencing cause gut bloating and increase both food consumption and body weight. These studies reveal that disrupting gut distension receptors changes feeding patterns and identify a key role for Drosophila Piezo in internal organ mechanosensation. KW - mechanosensation KW - sensory KW - Piezo KW - feeding KW - interoception JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -