TY - JOUR TI - COVID-19 CG enables SARS-CoV-2 mutation and lineage tracking by locations and dates of interest AU - Chen, Albert Tian AU - Altschuler, Kevin AU - Zhan, Shing Hei AU - Chan, Yujia Alina AU - Deverman, Benjamin E A2 - Bloom, Jesse D A2 - Davenport, Miles P VL - 10 PY - 2021 DA - 2021/02/23 SP - e63409 C1 - eLife 2021;10:e63409 DO - 10.7554/eLife.63409 UR - https://doi.org/10.7554/eLife.63409 AB - COVID-19 CG (covidcg.org) is an open resource for tracking SARS-CoV-2 single-nucleotide variations (SNVs), lineages, and clades using the virus genomes on the GISAID database while filtering by location, date, gene, and mutation of interest. COVID-19 CG provides significant time, labor, and cost-saving utility to projects on SARS-CoV-2 transmission, evolution, diagnostics, therapeutics, vaccines, and intervention tracking. Here, we describe case studies in which users can interrogate (1) SNVs in the SARS-CoV-2 spike receptor binding domain (RBD) across different geographical regions to inform the design and testing of therapeutics, (2) SNVs that may impact the sensitivity of commonly used diagnostic primers, and (3) the emergence of a dominant lineage harboring an S477N RBD mutation in Australia in 2020. To accelerate COVID-19 efforts, COVID-19 CG will be upgraded with new features for users to rapidly pinpoint mutations as the virus evolves throughout the pandemic and in response to therapeutic and public health interventions. KW - SARS-CoV-2 KW - COVID-19 KW - pandemic KW - browser KW - mutation tracking KW - resource JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -