TY - JOUR TI - Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring antibiotic-resistant bacterial pneumonia AU - Gregorova, Michaela AU - Morse, Daniel AU - Brignoli, Tarcisio AU - Steventon, Joseph AU - Hamilton, Fergus AU - Albur, Mahableshwar AU - Arnold, David AU - Thomas, Matthew AU - Halliday, Alice AU - Baum, Holly AU - Rice, Christopher AU - Avison, Matthew B AU - Davidson, Andrew D AU - Santopaolo, Marianna AU - Oliver, Elizabeth AU - Goenka, Anu AU - Finn, Adam AU - Wooldridge, Linda AU - Amulic, Borko AU - Boyton, Rosemary J AU - Altmann, Daniel M AU - Butler, David K AU - McMurray, Claire AU - Stockton, Joanna AU - Nicholls, Sam AU - Cooper, Charles AU - Loman, Nicholas AU - Cox, Michael J AU - Rivino, Laura AU - Massey, Ruth C A2 - Agrawal, Anurag A2 - Zaidi, Mone VL - 9 PY - 2020 DA - 2020/12/17 SP - e63430 C1 - eLife 2020;9:e63430 DO - 10.7554/eLife.63430 UR - https://doi.org/10.7554/eLife.63430 AB - Here, we describe the case of a COVID-19 patient who developed recurring ventilator-associated pneumonia caused by Pseudomonas aeruginosa that acquired increasing levels of antimicrobial resistance (AMR) in response to treatment. Metagenomic analysis revealed the AMR genotype, while immunological analysis revealed massive and escalating levels of T-cell activation. These were both SARS-CoV-2 and P. aeruginosa specific, and bystander activated, which may have contributed to this patient’s persistent symptoms and radiological changes. KW - SARS-CoV-2 KW - Pseudomonas aeruginosa KW - metagenomics KW - t-cells activation JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -