TY - JOUR TI - Independent and interacting value systems for reward and information in the human brain AU - Cogliati Dezza, Irene AU - Cleeremans, Axel AU - Alexander, William H A2 - Badre, David A2 - Frank, Michael J VL - 11 PY - 2022 DA - 2022/04/13 SP - e66358 C1 - eLife 2022;11:e66358 DO - 10.7554/eLife.66358 UR - https://doi.org/10.7554/eLife.66358 AB - Theories of prefrontal cortex (PFC) as optimizing reward value have been widely deployed to explain its activity in a diverse range of contexts, with substantial empirical support in neuroeconomics and decision neuroscience. Similar neural circuits, however, have also been associated with information processing. By using computational modeling, model-based functional magnetic resonance imaging analysis, and a novel experimental paradigm, we aim at establishing whether a dedicated and independent value system for information exists in the human PFC. We identify two regions in the human PFC that independently encode reward and information. Our results provide empirical evidence for PFC as an optimizer of independent information and reward signals during decision-making under realistic scenarios, with potential implications for the interpretation of PFC activity in both healthy and clinical populations. KW - PFC KW - RL KW - information JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -