1. Medicine

Insights from a Pan India Sero-Epidemiological survey (Phenome-India Cohort) for SARS-CoV2

  1. Salwa Naushin
  2. Viren Sardana
  3. Rajat Ujjainiya
  4. Nitin Bhatheja
  5. Rintu Kutum
  6. Akash Kumar Bhaskar
  7. Shalini Pradhan
  8. Satyartha Prakash
  9. Raju Khan
  10. Birendra Singh Rawat
  11. Karthik Bharadwaj Tallapaka
  12. Mahesh Anumalla
  13. Giriraj Ratan Chandak
  14. Amit Lahiri
  15. Susanta Kar
  16. Shrikant Ramesh Mulay
  17. Madhav Nilakanth Mugale
  18. Mrigank Srivastava
  19. Shaziya Khan
  20. Anjali Srivastava
  21. Bhawana Tomar
  22. Murugan Veerapandian
  23. Ganesh Venkatachalam
  24. Selvamani Raja Vijayakumar
  25. Ajay Agarwal
  26. Dinesh Gupta
  27. Prakash M Halami
  28. Muthukumar Serva Peddha
  29. Gopinath M Sundaram
  30. Ravindra P Veeranna
  31. Anirban Pal
  32. Vinay Kumar Agarwal
  33. Anil Ku Maurya
  34. Ranvijay Kumar Singh
  35. Ashok Kumar Raman
  36. Suresh Kumar Anandasadagopan
  37. Parimala Karuppanan
  38. Subramanian Venkatesan
  39. Harish Kumar Sardana
  40. Anamika Kothari
  41. Rishabh Jain
  42. Anupama Thakur
  43. Devendra Singh Parihar
  44. Anas Saifi
  45. Jasleen Kaur
  46. Virendra Kumar
  47. Avinash Mishra
  48. Iranna Gogeri
  49. Geethavani Rayasam
  50. Praveen Singh
  51. Rahul Chakraborty
  52. Gaura Chaturvedi
  53. Pinreddy Karunakar
  54. Rohit Yadav
  55. Sunanda Singhmar
  56. Dayanidhi Singh
  57. Sharmistha Sarkar
  58. Purbasha Bhattacharya
  59. Sundaram Acharya
  60. Vandana Singh
  61. Shweta Verma
  62. Drishti Soni
  63. Surabhi Seth
  64. Sakshi Vashisht
  65. Sarita Thakran
  66. Firdaus Fatima
  67. Akash Pratap Singh
  68. Akanksha Sharma
  69. Babita Sharma
  70. Manikandan Subramanian
  71. Yogendra S Padwad
  72. Vipin Hallan
  73. Vikram Patial
  74. Damanpreet Singh
  75. Narendra Vijay Tripude
  76. Partha Chakrabarti
  77. Sujay Krishna Maity
  78. Dipyaman Ganguly
  79. Jit Sarkar
  80. Sistla Ramakrishna
  81. Balthu Narender Kumar
  82. Kiran A Kumar
  83. Sumit G Gandhi
  84. Piyush Singh Jamwal
  85. Rekha Chouhan
  86. Vijay Lakshmi Jamwal
  87. Nitika Kapoor
  88. Debashish Ghosh
  89. Ghanshyam Thakkar
  90. Umakanta Subudhi
  91. Pradip Sen
  92. Saumya Ray Chaudhury
  93. Rashmi Kumar
  94. Pawan Gupta
  95. Amit Tuli
  96. Deepak Sharma
  97. Rajesh P Ringe
  98. Amarnarayan D
  99. Mahesh Kulkarni
  100. Dhansekaran Shanmugam
  101. Mahesh S Dharne
  102. Sayed G Dastager
  103. Rakesh Joshi
  104. Amita P Patil
  105. Sachin N Mahajan
  106. Abujunaid Habib Khan
  107. Vasudev Wagh
  108. Rakesh Kumar Yadav
  109. Ajinkya Khilari
  110. Mayuri Bhadange
  111. Arvindkumar H Chaurasiya
  112. Shabda E Kulsange
  113. Krishna Khairnar
  114. Shilpa Paranjape
  115. Jatin Kalita
  116. Narahari G Sastry
  117. Tridip Phukan
  118. Prasenjit Manna
  119. Wahengbam Romi
  120. Pankaj Bharali
  121. Dibyajyoti Ozah
  122. Ravi Kumar Sahu
  123. Elapavalooru VSSK Babu
  124. Rajeev Sukumaran
  125. Aiswarya R Nair
  126. Prajeesh Kooloth Valappil
  127. Anoop Puthiyamadam
  128. Adarsh Velayudhanpillai
  129. Kalpana Chodankar
  130. Samir Damare
  131. Yennapu Madhavi
  132. Ved Varun Aggarwal
  133. Sumit Dahiya
  134. Anurag Agrawal
  135. Debasis Dash  Is a corresponding author
  136. Shantanu Sengupta  Is a corresponding author
  1. CSIR-Institute of Genomics and Integrative Biology, India
  2. CSIR-AMPRI, India
  3. CSIR-CBRI, India
  4. CSIR-CCMB, India
  5. CSIR-CDRI, India
  6. CSIR-CECRI, India
  7. CSIR-CEERI, India
  8. CSIR-CFTRI, India
  9. CSIR-CIMAP, India
  10. CSIR-CIMFR, India
  11. CSIR-CLRI, India
  12. CSIR-CSIO, India
  13. CSIR-CSMCRI, India
  14. CSIR-4PI, India
  15. CSIR, India
  16. CSIR-IGIB, India
  17. CSIR-Institute of Himalayan Bioresource Technology (CSIR-IHBT), India
  18. CSIR-IHBT, India
  19. CSIR-IICB, India
  20. CSIR-IICT, India
  21. CSIR-IIIM, India
  22. CSIR-IIP, India
  23. CSIR-IMMT, India
  24. CSIR-IMTECH, India
  25. Institute of Microbial Technology, India
  26. CSIR-NAL, India
  27. National Chemical Laboratory, India
  28. CSIR-National Chemical Laboratory, India
  29. CSIR-NCL, India
  30. CSIR-NEERI, India
  31. CSIR-NEIST, India
  32. CSIR-NGRI, India
  33. CSIR-NIIST, India
  34. CSIR-NIO, India
  35. CSIR-NISTADS, India
  36. CSIR-NPL, India
  37. CSIR Institute of Genomics and Integrative Biology, India
  38. CSIR - Institute of Genomics and Integrative Biology, Delhi, India
https://doi.org/10.7554/eLife.66537
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Cite this article
  1. Salwa Naushin
  2. Viren Sardana
  3. Rajat Ujjainiya
  4. Nitin Bhatheja
  5. Rintu Kutum
  6. Akash Kumar Bhaskar
  7. Shalini Pradhan
  8. Satyartha Prakash
  9. Raju Khan
  10. Birendra Singh Rawat
  11. Karthik Bharadwaj Tallapaka
  12. Mahesh Anumalla
  13. Giriraj Ratan Chandak
  14. Amit Lahiri
  15. Susanta Kar
  16. Shrikant Ramesh Mulay
  17. Madhav Nilakanth Mugale
  18. Mrigank Srivastava
  19. Shaziya Khan
  20. Anjali Srivastava
  21. Bhawana Tomar
  22. Murugan Veerapandian
  23. Ganesh Venkatachalam
  24. Selvamani Raja Vijayakumar
  25. Ajay Agarwal
  26. Dinesh Gupta
  27. Prakash M Halami
  28. Muthukumar Serva Peddha
  29. Gopinath M Sundaram
  30. Ravindra P Veeranna
  31. Anirban Pal
  32. Vinay Kumar Agarwal
  33. Anil Ku Maurya
  34. Ranvijay Kumar Singh
  35. Ashok Kumar Raman
  36. Suresh Kumar Anandasadagopan
  37. Parimala Karuppanan
  38. Subramanian Venkatesan
  39. Harish Kumar Sardana
  40. Anamika Kothari
  41. Rishabh Jain
  42. Anupama Thakur
  43. Devendra Singh Parihar
  44. Anas Saifi
  45. Jasleen Kaur
  46. Virendra Kumar
  47. Avinash Mishra
  48. Iranna Gogeri
  49. Geethavani Rayasam
  50. Praveen Singh
  51. Rahul Chakraborty
  52. Gaura Chaturvedi
  53. Pinreddy Karunakar
  54. Rohit Yadav
  55. Sunanda Singhmar
  56. Dayanidhi Singh
  57. Sharmistha Sarkar
  58. Purbasha Bhattacharya
  59. Sundaram Acharya
  60. Vandana Singh
  61. Shweta Verma
  62. Drishti Soni
  63. Surabhi Seth
  64. Sakshi Vashisht
  65. Sarita Thakran
  66. Firdaus Fatima
  67. Akash Pratap Singh
  68. Akanksha Sharma
  69. Babita Sharma
  70. Manikandan Subramanian
  71. Yogendra S Padwad
  72. Vipin Hallan
  73. Vikram Patial
  74. Damanpreet Singh
  75. Narendra Vijay Tripude
  76. Partha Chakrabarti
  77. Sujay Krishna Maity
  78. Dipyaman Ganguly
  79. Jit Sarkar
  80. Sistla Ramakrishna
  81. Balthu Narender Kumar
  82. Kiran A Kumar
  83. Sumit G Gandhi
  84. Piyush Singh Jamwal
  85. Rekha Chouhan
  86. Vijay Lakshmi Jamwal
  87. Nitika Kapoor
  88. Debashish Ghosh
  89. Ghanshyam Thakkar
  90. Umakanta Subudhi
  91. Pradip Sen
  92. Saumya Ray Chaudhury
  93. Rashmi Kumar
  94. Pawan Gupta
  95. Amit Tuli
  96. Deepak Sharma
  97. Rajesh P Ringe
  98. Amarnarayan D
  99. Mahesh Kulkarni
  100. Dhansekaran Shanmugam
  101. Mahesh S Dharne
  102. Sayed G Dastager
  103. Rakesh Joshi
  104. Amita P Patil
  105. Sachin N Mahajan
  106. Abujunaid Habib Khan
  107. Vasudev Wagh
  108. Rakesh Kumar Yadav
  109. Ajinkya Khilari
  110. Mayuri Bhadange
  111. Arvindkumar H Chaurasiya
  112. Shabda E Kulsange
  113. Krishna Khairnar
  114. Shilpa Paranjape
  115. Jatin Kalita
  116. Narahari G Sastry
  117. Tridip Phukan
  118. Prasenjit Manna
  119. Wahengbam Romi
  120. Pankaj Bharali
  121. Dibyajyoti Ozah
  122. Ravi Kumar Sahu
  123. Elapavalooru VSSK Babu
  124. Rajeev Sukumaran
  125. Aiswarya R Nair
  126. Prajeesh Kooloth Valappil
  127. Anoop Puthiyamadam
  128. Adarsh Velayudhanpillai
  129. Kalpana Chodankar
  130. Samir Damare
  131. Yennapu Madhavi
  132. Ved Varun Aggarwal
  133. Sumit Dahiya
  134. Anurag Agrawal
  135. Debasis Dash
  136. Shantanu Sengupta
(2021)
Insights from a Pan India Sero-Epidemiological survey (Phenome-India Cohort) for SARS-CoV2
eLife 10:e66537.
https://doi.org/10.7554/eLife.66537
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  3. Download .RIS

Abstract

To understand the spread of SARS-CoV2, in August and September 2020, the Council of Scientific and Industrial Research (India), conducted a sero-survey across its constituent laboratories and centers across India. Of 10,427 volunteers, 1058 (10.14%) tested positive for SARS CoV2 anti-nucleocapsid (anti-NC) antibodies; 95% of which had surrogate neutralization activity. Three-fourth of these recalled no symptoms. Repeat serology tests at 3 (n=607) and 6 (n=175) months showed stable anti-NC antibodies but declining neutralization activity. Local sero-positivity was higher in densely populated cities and was inversely correlated with a 30 day change in regional test positivity rates (TPR). Regional seropositivity above 10% was associated with declining TPR. Personal factors associated with higher odds of sero-positivity were high-exposure work (Odds Ratio, 95% CI, p value; 2∙23, 1∙92–2∙59, <0.0001), use of public transport (1∙79, 1∙43–2∙24, <0.0001), not smoking (1∙52, 1∙16–1∙99, 0∙0257), non-vegetarian diet (1∙67, 1∙41–1∙99, <0.0001), and B blood group (1∙36,1∙15-1∙61, 0∙001).

Data availability

Source data files have been provided for Figures 1 ,2,3 and 4. For Figure 2B , data is available in source data file and the district wise data listed in the source file on the number of confirmed cases and tests was taken from https://www.covid19india.org/.From this site, the data has to be manually extracted for desired time points by manually hovering over the number of cases and tests done graph when a district is selected after selection of the state. Code of Data Analysis and Model Definition Files- Available on Github https://github.com/rintukutum/pan-india-csir-sero-epi

Article and author information

Author details

  1. Salwa Naushin

    Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, Delhi, India
    Competing interests
    The authors declare that no competing interests exist.

  2. Viren Sardana

    Informatics and Big Data, CSIR-Institute of Genomics and Integrative Biology, Delhi, India
    Competing interests
    The authors declare that no competing interests exist.

  3. Rajat Ujjainiya

    Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, Delhi, India
    Competing interests
    The authors declare that no competing interests exist.

  4. Nitin Bhatheja

    Informatics and Big Data, CSIR-Institute of Genomics and Integrative Biology, Delhi, India
    Competing interests
    The authors declare that no competing interests exist.

  5. Rintu Kutum

    Informatics and Big Data, CSIR-Institute of Genomics and Integrative Biology, Delhi, India
    Competing interests
    The authors declare that no competing interests exist.

  6. Akash Kumar Bhaskar

    Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, Delhi, India
    Competing interests
    The authors declare that no competing interests exist.

  7. Shalini Pradhan

    Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, Delhi, India
    Competing interests
    The authors declare that no competing interests exist.

  8. Satyartha Prakash

    Informatics and Big Data, CSIR-Institute of Genomics and Integrative Biology, Delhi, India
    Competing interests
    The authors declare that no competing interests exist.

  9. Raju Khan

    AMPRI, CSIR-AMPRI, Delhi, India
    Competing interests
    The authors declare that no competing interests exist.

  10. Birendra Singh Rawat

    CBRI, CSIR-CBRI, Roorkee, India
    Competing interests
    The authors declare that no competing interests exist.

  11. Karthik Bharadwaj Tallapaka

    CCMB, CSIR-CCMB, Hyderabad, India
    Competing interests
    The authors declare that no competing interests exist.

  12. Mahesh Anumalla

    CCMB, CSIR-CCMB, Hyderabad, India
    Competing interests
    The authors declare that no competing interests exist.

  13. Giriraj Ratan Chandak

    CCMB, CSIR-CCMB, Hyderabad, India
    Competing interests
    The authors declare that no competing interests exist.

  14. Amit Lahiri

    CDRI, CSIR-CDRI, Lucknow, India
    Competing interests
    The authors declare that no competing interests exist.

  15. Susanta Kar

    CDRI, CSIR-CDRI, Lucknow, India
    Competing interests
    The authors declare that no competing interests exist.

  16. Shrikant Ramesh Mulay

    CDRI, CSIR-CDRI, Lucknow, India
    Competing interests
    The authors declare that no competing interests exist.

  17. Madhav Nilakanth Mugale

    CDRI, CSIR-CDRI, Lucknow, India
    Competing interests
    The authors declare that no competing interests exist.

  18. Mrigank Srivastava

    CDRI, CSIR-CDRI, Lucknow, India
    Competing interests
    The authors declare that no competing interests exist.

  19. Shaziya Khan

    CDRI, CSIR-CDRI, Lucknow, India
    Competing interests
    The authors declare that no competing interests exist.

  20. Anjali Srivastava

    CDRI, CSIR-CDRI, Lucknow, India
    Competing interests
    The authors declare that no competing interests exist.

  21. Bhawana Tomar

    CDRI, CSIR-CDRI, Lucknow, India
    Competing interests
    The authors declare that no competing interests exist.

  22. Murugan Veerapandian

    CECRI, CSIR-CECRI, Karaikudi, India
    Competing interests
    The authors declare that no competing interests exist.

  23. Ganesh Venkatachalam

    CECRI, CSIR-CECRI, Karaikudi, India
    Competing interests
    The authors declare that no competing interests exist.

  24. Selvamani Raja Vijayakumar

    CECRI, CSIR-CECRI, Karaikudi, India
    Competing interests
    The authors declare that no competing interests exist.

  25. Ajay Agarwal

    CEERI, CSIR-CEERI, Pilani, India
    Competing interests
    The authors declare that no competing interests exist.

  26. Dinesh Gupta

    CEERI, CSIR-CEERI, Pilani, India
    Competing interests
    The authors declare that no competing interests exist.

  27. Prakash M Halami

    CFTRI, CSIR-CFTRI, Mysore, India
    Competing interests
    The authors declare that no competing interests exist.

  28. Muthukumar Serva Peddha

    CFTRI, CSIR-CFTRI, Mysore, India
    Competing interests
    The authors declare that no competing interests exist.

  29. Gopinath M Sundaram

    CFTRI, CSIR-CFTRI, Mysore, India
    Competing interests
    The authors declare that no competing interests exist.

  30. Ravindra P Veeranna

    CFTRI, CSIR-CFTRI, Mysore, India
    Competing interests
    The authors declare that no competing interests exist.

  31. Anirban Pal

    CIMAP, CSIR-CIMAP, Lucknow, India
    Competing interests
    The authors declare that no competing interests exist.

  32. Vinay Kumar Agarwal

    CIMAP, CSIR-CIMAP, Lucknow, India
    Competing interests
    The authors declare that no competing interests exist.

  33. Anil Ku Maurya

    CIMAP, CSIR-CIMAP, Lucknow, India
    Competing interests
    The authors declare that no competing interests exist.

  34. Ranvijay Kumar Singh

    CIMFR, CSIR-CIMFR, Dhanbad, India
    Competing interests
    The authors declare that no competing interests exist.

  35. Ashok Kumar Raman

    CIMFR, CSIR-CIMFR, Dhanbad, India
    Competing interests
    The authors declare that no competing interests exist.

  36. Suresh Kumar Anandasadagopan

    CLRI, CSIR-CLRI, Chennai, India
    Competing interests
    The authors declare that no competing interests exist.

  37. Parimala Karuppanan

    CLRI, CSIR-CLRI, Chennai, India
    Competing interests
    The authors declare that no competing interests exist.

  38. Subramanian Venkatesan

    CLRI, CSIR-CLRI, Chennai, India
    Competing interests
    The authors declare that no competing interests exist.

  39. Harish Kumar Sardana

    CSIO, CSIR-CSIO, Chandigarh, India
    Competing interests
    The authors declare that no competing interests exist.

  40. Anamika Kothari

    CSIO, CSIR-CSIO, Chandigarh, India
    Competing interests
    The authors declare that no competing interests exist.

  41. Rishabh Jain

    CSIO, CSIR-CSIO, Chandigarh, India
    Competing interests
    The authors declare that no competing interests exist.

  42. Anupama Thakur

    CSIO, CSIR-CSIO, Chandigarh, India
    Competing interests
    The authors declare that no competing interests exist.

  43. Devendra Singh Parihar

    CSIO, CSIR-CSIO, Chandigarh, India
    Competing interests
    The authors declare that no competing interests exist.

  44. Anas Saifi

    CSIO, CSIR-CSIO, Chandigarh, India
    Competing interests
    The authors declare that no competing interests exist.

  45. Jasleen Kaur

    CSIO, CSIR-CSIO, Chandigarh, India
    Competing interests
    The authors declare that no competing interests exist.

  46. Virendra Kumar

    CSIO, CSIR-CSIO, Chandigarh, India
    Competing interests
    The authors declare that no competing interests exist.

  47. Avinash Mishra

    CSMCRI, CSIR-CSMCRI, Bhavnagar, India
    Competing interests
    The authors declare that no competing interests exist.

  48. Iranna Gogeri

    4PI, CSIR-4PI, Bengaluru, India
    Competing interests
    The authors declare that no competing interests exist.

  49. Geethavani Rayasam

    Headquarters, CSIR, New Delhi, India
    Competing interests
    The authors declare that no competing interests exist.

  50. Praveen Singh

    IGIB, CSIR-IGIB, New Delhi, India
    Competing interests
    The authors declare that no competing interests exist.

  51. Rahul Chakraborty

    CSIR-Institute of Genomics and Integrative Biology, New Delhi, India
    Competing interests
    The authors declare that no competing interests exist.

  52. Gaura Chaturvedi

    IGIB, CSIR-IGIB, New Delhi, India
    Competing interests
    The authors declare that no competing interests exist.

  53. Pinreddy Karunakar

    IGIB, CSIR-IGIB, New Delhi, India
    Competing interests
    The authors declare that no competing interests exist.

  54. Rohit Yadav

    IGIB, CSIR-IGIB, New Delhi, India
    Competing interests
    The authors declare that no competing interests exist.

  55. Sunanda Singhmar

    IGIB, CSIR-IGIB, New Delhi, India
    Competing interests
    The authors declare that no competing interests exist.

  56. Dayanidhi Singh

    IGIB, CSIR-IGIB, New Delhi, India
    Competing interests
    The authors declare that no competing interests exist.

  57. Sharmistha Sarkar

    IGIB, CSIR-IGIB, New Delhi, India
    Competing interests
    The authors declare that no competing interests exist.

  58. Purbasha Bhattacharya

    IGIB, CSIR-IGIB, New Delhi, India
    Competing interests
    The authors declare that no competing interests exist.

  59. Sundaram Acharya

    IGIB, CSIR-IGIB, New Delhi, India
    Competing interests
    The authors declare that no competing interests exist.

  60. Vandana Singh

    IGIB, CSIR-IGIB, New Delhi, India
    Competing interests
    The authors declare that no competing interests exist.

  61. Shweta Verma

    IGIB, CSIR-IGIB, New Delhi, India
    Competing interests
    The authors declare that no competing interests exist.

  62. Drishti Soni

    IGIB, CSIR-IGIB, New Delhi, India
    Competing interests
    The authors declare that no competing interests exist.

  63. Surabhi Seth

    IGIB, CSIR-IGIB, New Delhi, India
    Competing interests
    The authors declare that no competing interests exist.

  64. Sakshi Vashisht

    IGIB, CSIR-IGIB, New Delhi, India
    Competing interests
    The authors declare that no competing interests exist.

  65. Sarita Thakran

    IGIB, CSIR-IGIB, New Delhi, India
    Competing interests
    The authors declare that no competing interests exist.

  66. Firdaus Fatima

    IGIB, CSIR-IGIB, New Delhi, India
    Competing interests
    The authors declare that no competing interests exist.

  67. Akash Pratap Singh

    IGIB, CSIR-IGIB, New Delhi, India
    Competing interests
    The authors declare that no competing interests exist.

  68. Akanksha Sharma

    IGIB, CSIR-IGIB, New Delhi, India
    Competing interests
    The authors declare that no competing interests exist.

  69. Babita Sharma

    IGIB, CSIR-IGIB, New Delhi, India
    Competing interests
    The authors declare that no competing interests exist.

  70. Manikandan Subramanian

    IGIB, CSIR-IGIB, New Delhi, India
    Competing interests
    The authors declare that no competing interests exist.

  71. Yogendra S Padwad

    Pharmacology and Toxicology Laboratory, Food and Nutraceuticals Division, CSIR-Institute of Himalayan Bioresource Technology (CSIR-IHBT), Palampur, India
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0003-1793-9340

  72. Vipin Hallan

    IHBT, CSIR-IHBT, Palampur, India
    Competing interests
    The authors declare that no competing interests exist.

  73. Vikram Patial

    IHBT, CSIR-IHBT, Palampur, India
    Competing interests
    The authors declare that no competing interests exist.

  74. Damanpreet Singh

    IHBT, CSIR-IHBT, Palampur, India
    Competing interests
    The authors declare that no competing interests exist.

  75. Narendra Vijay Tripude

    IHBT, CSIR-IHBT, Palampur, India
    Competing interests
    The authors declare that no competing interests exist.

  76. Partha Chakrabarti

    IICB, CSIR-IICB, Kolkata, India
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0001-9502-8695

  77. Sujay Krishna Maity

    IICB, CSIR-IICB, Kolkata, India
    Competing interests
    The authors declare that no competing interests exist.

  78. Dipyaman Ganguly

    IICB, CSIR-IICB, Kolkata, India
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-7786-1795

  79. Jit Sarkar

    IICB, CSIR-IICB, Kolkata, India
    Competing interests
    The authors declare that no competing interests exist.

  80. Sistla Ramakrishna

    IICT, CSIR-IICT, Hyderabad, India
    Competing interests
    The authors declare that no competing interests exist.

  81. Balthu Narender Kumar

    IICT, CSIR-IICT, Hyderabad, India
    Competing interests
    The authors declare that no competing interests exist.

  82. Kiran A Kumar

    IICT, CSIR-IICT, Hyderabad, India
    Competing interests
    The authors declare that no competing interests exist.

  83. Sumit G Gandhi

    IIIM, CSIR-IIIM, Jammu, India
    Competing interests
    The authors declare that no competing interests exist.

  84. Piyush Singh Jamwal

    IIIM, CSIR-IIIM, Jammu, India
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-6640-7079

  85. Rekha Chouhan

    IIIM, CSIR-IIIM, Jammu, India
    Competing interests
    The authors declare that no competing interests exist.

  86. Vijay Lakshmi Jamwal

    IIIM, CSIR-IIIM, Jammu, India
    Competing interests
    The authors declare that no competing interests exist.

  87. Nitika Kapoor

    IIIM, CSIR-IIIM, Jammu, India
    Competing interests
    The authors declare that no competing interests exist.

  88. Debashish Ghosh

    IIP, CSIR-IIP, Dehradun, India
    Competing interests
    The authors declare that no competing interests exist.

  89. Ghanshyam Thakkar

    IIP, CSIR-IIP, Dehradun, India
    Competing interests
    The authors declare that no competing interests exist.

  90. Umakanta Subudhi

    IMMT, CSIR-IMMT, Bhubaneshwar, India
    Competing interests
    The authors declare that no competing interests exist.

  91. Pradip Sen

    IMTECH, CSIR-IMTECH, Chandigarh, India
    Competing interests
    The authors declare that no competing interests exist.

  92. Saumya Ray Chaudhury

    IMTECH, CSIR-IMTECH, Chandigarh, India
    Competing interests
    The authors declare that no competing interests exist.

  93. Rashmi Kumar

    IMTECH, CSIR-IMTECH, Chandigarh, India
    Competing interests
    The authors declare that no competing interests exist.

  94. Pawan Gupta

    IMTECH, CSIR-IMTECH, Chandigarh, India
    Competing interests
    The authors declare that no competing interests exist.

  95. Amit Tuli

    IMTECH, CSIR-IMTECH, Chandigarh, India
    Competing interests
    The authors declare that no competing interests exist.

  96. Deepak Sharma

    G. N. Ramachandran Protein Centre, Institute of Microbial Technology, Chandigarh, India
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0003-1104-575X

  97. Rajesh P Ringe

    IMTECH, CSIR-IMTECH, Chandigarh, India
    Competing interests
    The authors declare that no competing interests exist.

  98. Amarnarayan D

    NAL, CSIR-NAL, Bengaluru, India
    Competing interests
    The authors declare that no competing interests exist.

  99. Mahesh Kulkarni

    Division of Biochemical Sciences, National Chemical Laboratory, Pune, India
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0003-3932-9092

  100. Dhansekaran Shanmugam

    Biochemical Sciences Division, CSIR-National Chemical Laboratory, Pune, India
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-3341-4846

  101. Mahesh S Dharne

    NCL, CSIR-NCL, Pune, India
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-3965-7320

  102. Sayed G Dastager

    NCL, CSIR-NCL, Pune, India
    Competing interests
    The authors declare that no competing interests exist.

  103. Rakesh Joshi

    NCL, CSIR-NCL, Pune, India
    Competing interests
    The authors declare that no competing interests exist.

  104. Amita P Patil

    NCL, CSIR-NCL, Pune, India
    Competing interests
    The authors declare that no competing interests exist.

  105. Sachin N Mahajan

    NCL, CSIR-NCL, Pune, India
    Competing interests
    The authors declare that no competing interests exist.

  106. Abujunaid Habib Khan

    NCL, CSIR-NCL, Pune, India
    Competing interests
    The authors declare that no competing interests exist.

  107. Vasudev Wagh

    NCL, CSIR-NCL, Pune, India
    Competing interests
    The authors declare that no competing interests exist.

  108. Rakesh Kumar Yadav

    NCL, CSIR-NCL, Pune, India
    Competing interests
    The authors declare that no competing interests exist.

  109. Ajinkya Khilari

    NCL, CSIR-NCL, Pune, India
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-5884-8747

  110. Mayuri Bhadange

    NCL, CSIR-NCL, Pune, India
    Competing interests
    The authors declare that no competing interests exist.

  111. Arvindkumar H Chaurasiya

    NCL, CSIR-NCL, Pune, India
    Competing interests
    The authors declare that no competing interests exist.

  112. Shabda E Kulsange

    NCL, CSIR-NCL, Pune, India
    Competing interests
    The authors declare that no competing interests exist.

  113. Krishna Khairnar

    NEERI, CSIR-NEERI, Nagpur, India
    Competing interests
    The authors declare that no competing interests exist.

  114. Shilpa Paranjape

    NEERI, CSIR-NEERI, Nagpur, India
    Competing interests
    The authors declare that no competing interests exist.

  115. Jatin Kalita

    NEIST, CSIR-NEIST, Jorhat, India
    Competing interests
    The authors declare that no competing interests exist.

  116. Narahari G Sastry

    NEIST, CSIR-NEIST, Jorhat, India
    Competing interests
    The authors declare that no competing interests exist.

  117. Tridip Phukan

    NEIST, CSIR-NEIST, Jorhat, India
    Competing interests
    The authors declare that no competing interests exist.

  118. Prasenjit Manna

    NEIST, CSIR-NEIST, Jorhat, India
    Competing interests
    The authors declare that no competing interests exist.

  119. Wahengbam Romi

    NEIST, CSIR-NEIST, Jorhat, India
    Competing interests
    The authors declare that no competing interests exist.

  120. Pankaj Bharali

    NEIST, CSIR-NEIST, Jorhat, India
    Competing interests
    The authors declare that no competing interests exist.

  121. Dibyajyoti Ozah

    NEIST, CSIR-NEIST, Jorhat, India
    Competing interests
    The authors declare that no competing interests exist.

  122. Ravi Kumar Sahu

    NEIST, CSIR-NEIST, Jorhat, India
    Competing interests
    The authors declare that no competing interests exist.

  123. Elapavalooru VSSK Babu

    NGRI, CSIR-NGRI, Hyderabad, India
    Competing interests
    The authors declare that no competing interests exist.

  124. Rajeev Sukumaran

    NIIST, CSIR-NIIST, Thiruvananthapuram, India
    Competing interests
    The authors declare that no competing interests exist.

  125. Aiswarya R Nair

    NIIST, CSIR-NIIST, Thiruvananthapuram, India
    Competing interests
    The authors declare that no competing interests exist.

  126. Prajeesh Kooloth Valappil

    NIIST, CSIR-NIIST, Thiruvananthapuram, India
    Competing interests
    The authors declare that no competing interests exist.

  127. Anoop Puthiyamadam

    NIIST, CSIR-NIIST, Thiruvananthapuram, India
    Competing interests
    The authors declare that no competing interests exist.

  128. Adarsh Velayudhanpillai

    NIIST, CSIR-NIIST, Thiruvananthapuram, India
    Competing interests
    The authors declare that no competing interests exist.

  129. Kalpana Chodankar

    NIO, CSIR-NIO, Goa, India
    Competing interests
    The authors declare that no competing interests exist.

  130. Samir Damare

    NIO, CSIR-NIO, Goa, India
    Competing interests
    The authors declare that no competing interests exist.

  131. Yennapu Madhavi

    NISTADS, CSIR-NISTADS, New Delhi, India
    Competing interests
    The authors declare that no competing interests exist.

  132. Ved Varun Aggarwal

    NPL, CSIR-NPL, New Delhi, India
    Competing interests
    The authors declare that no competing interests exist.

  133. Sumit Dahiya

    NPL, CSIR-NPL, New Delhi, India
    Competing interests
    The authors declare that no competing interests exist.

  134. Anurag Agrawal

    CSIR Institute of Genomics and Integrative Biology, New Delhi, India
    Competing interests
    The authors declare that no competing interests exist.

  135. Debasis Dash

    CSIR - Institute of Genomics and Integrative Biology, Delhi, New Delhi, India
    For correspondence
    ddash@igib.res.in
    Competing interests
    The authors declare that no competing interests exist.

  136. Shantanu Sengupta

    Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, Delhi, India
    For correspondence
    shantanus@igib.res.in
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0001-8461-0735

Funding

Council of Scientific and Industrial Research, India (MLP-2007)

  • Shantanu Sengupta

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Reviewing Editor

  1. Jameel Iqbal, James J Peters Veterans Affairs Medical Center, United States

Ethics

Human subjects: The longitudinal cohort study was approved by Institutional Human Ethics Committee of CSIR-IGIB vide approval CSIR-IGIB/IHEC/2019-20. The participation was voluntary, and participants had to fill an online informed consent with a consent to publish and share findings and deidentified data

Version history

  1. Received: January 14, 2021
  2. Accepted: April 9, 2021
  3. Accepted Manuscript published: April 20, 2021 (version 1)
  4. Version of Record published: May 13, 2021 (version 2)

Copyright

© 2021, Naushin et al.

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

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  1. Salwa Naushin
  2. Viren Sardana
  3. Rajat Ujjainiya
  4. Nitin Bhatheja
  5. Rintu Kutum
  6. Akash Kumar Bhaskar
  7. Shalini Pradhan
  8. Satyartha Prakash
  9. Raju Khan
  10. Birendra Singh Rawat
  11. Karthik Bharadwaj Tallapaka
  12. Mahesh Anumalla
  13. Giriraj Ratan Chandak
  14. Amit Lahiri
  15. Susanta Kar
  16. Shrikant Ramesh Mulay
  17. Madhav Nilakanth Mugale
  18. Mrigank Srivastava
  19. Shaziya Khan
  20. Anjali Srivastava
  21. Bhawana Tomar
  22. Murugan Veerapandian
  23. Ganesh Venkatachalam
  24. Selvamani Raja Vijayakumar
  25. Ajay Agarwal
  26. Dinesh Gupta
  27. Prakash M Halami
  28. Muthukumar Serva Peddha
  29. Gopinath M Sundaram
  30. Ravindra P Veeranna
  31. Anirban Pal
  32. Vinay Kumar Agarwal
  33. Anil Ku Maurya
  34. Ranvijay Kumar Singh
  35. Ashok Kumar Raman
  36. Suresh Kumar Anandasadagopan
  37. Parimala Karuppanan
  38. Subramanian Venkatesan
  39. Harish Kumar Sardana
  40. Anamika Kothari
  41. Rishabh Jain
  42. Anupama Thakur
  43. Devendra Singh Parihar
  44. Anas Saifi
  45. Jasleen Kaur
  46. Virendra Kumar
  47. Avinash Mishra
  48. Iranna Gogeri
  49. Geethavani Rayasam
  50. Praveen Singh
  51. Rahul Chakraborty
  52. Gaura Chaturvedi
  53. Pinreddy Karunakar
  54. Rohit Yadav
  55. Sunanda Singhmar
  56. Dayanidhi Singh
  57. Sharmistha Sarkar
  58. Purbasha Bhattacharya
  59. Sundaram Acharya
  60. Vandana Singh
  61. Shweta Verma
  62. Drishti Soni
  63. Surabhi Seth
  64. Sakshi Vashisht
  65. Sarita Thakran
  66. Firdaus Fatima
  67. Akash Pratap Singh
  68. Akanksha Sharma
  69. Babita Sharma
  70. Manikandan Subramanian
  71. Yogendra S Padwad
  72. Vipin Hallan
  73. Vikram Patial
  74. Damanpreet Singh
  75. Narendra Vijay Tripude
  76. Partha Chakrabarti
  77. Sujay Krishna Maity
  78. Dipyaman Ganguly
  79. Jit Sarkar
  80. Sistla Ramakrishna
  81. Balthu Narender Kumar
  82. Kiran A Kumar
  83. Sumit G Gandhi
  84. Piyush Singh Jamwal
  85. Rekha Chouhan
  86. Vijay Lakshmi Jamwal
  87. Nitika Kapoor
  88. Debashish Ghosh
  89. Ghanshyam Thakkar
  90. Umakanta Subudhi
  91. Pradip Sen
  92. Saumya Ray Chaudhury
  93. Rashmi Kumar
  94. Pawan Gupta
  95. Amit Tuli
  96. Deepak Sharma
  97. Rajesh P Ringe
  98. Amarnarayan D
  99. Mahesh Kulkarni
  100. Dhansekaran Shanmugam
  101. Mahesh S Dharne
  102. Sayed G Dastager
  103. Rakesh Joshi
  104. Amita P Patil
  105. Sachin N Mahajan
  106. Abujunaid Habib Khan
  107. Vasudev Wagh
  108. Rakesh Kumar Yadav
  109. Ajinkya Khilari
  110. Mayuri Bhadange
  111. Arvindkumar H Chaurasiya
  112. Shabda E Kulsange
  113. Krishna Khairnar
  114. Shilpa Paranjape
  115. Jatin Kalita
  116. Narahari G Sastry
  117. Tridip Phukan
  118. Prasenjit Manna
  119. Wahengbam Romi
  120. Pankaj Bharali
  121. Dibyajyoti Ozah
  122. Ravi Kumar Sahu
  123. Elapavalooru VSSK Babu
  124. Rajeev Sukumaran
  125. Aiswarya R Nair
  126. Prajeesh Kooloth Valappil
  127. Anoop Puthiyamadam
  128. Adarsh Velayudhanpillai
  129. Kalpana Chodankar
  130. Samir Damare
  131. Yennapu Madhavi
  132. Ved Varun Aggarwal
  133. Sumit Dahiya
  134. Anurag Agrawal
  135. Debasis Dash
  136. Shantanu Sengupta
(2021)
Insights from a Pan India Sero-Epidemiological survey (Phenome-India Cohort) for SARS-CoV2
eLife 10:e66537.
https://doi.org/10.7554/eLife.66537

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    Irisin, released from exercised muscle, has been shown to have beneficial effects on numerous tissues but its effects on bone are unclear. We found significant sex and genotype differences in bone from wildtype (WT) mice compared to mice lacking Fndc5 (knockout [KO]), with and without calcium deficiency. Despite their bone being indistinguishable from WT females, KO female mice were partially protected from osteocytic osteolysis and osteoclastic bone resorption when allowed to lactate or when placed on a low-calcium diet. Male KO mice have more but weaker bone compared to WT males, and when challenged with a low-calcium diet lost more bone than WT males. To begin to understand responsible molecular mechanisms, osteocyte transcriptomics was performed. Osteocytes from WT females had greater expression of genes associated with osteocytic osteolysis and osteoclastic bone resorption compared to WT males which had greater expression of genes associated with steroid and fatty acid metabolism. Few differences were observed between female KO and WT osteocytes, but with a low-calcium diet, the KO females had lower expression of genes responsible for osteocytic osteolysis and osteoclastic resorption than the WT females. Male KO osteocytes had lower expression of genes associated with steroid and fatty acid metabolism, but higher expression of genes associated with bone resorption compared to male WT. In conclusion, irisin plays a critical role in the development of the male but not the female skeleton and protects male but not female bone from calcium deficiency. We propose irisin ensures the survival of offspring by targeting the osteocyte to provide calcium in lactating females, a novel function for this myokine.