Science Forum: Is preclinical research in cancer biology reproducible enough?
- Studies in Translation, Ethics and Medicine, Biomedical Ethics Unit, McGill University, Canada
Figures
Figure 1
The positive likelihood ratio as a function of the Positive Predictive Value (PPV) and the base rate.
The positive likelihood ratio (y-axis) increases with the PPV (x-axis) for a given value of the base rate (see color code). However, for a given value of the PPV, the positive likelihood ratio decreases as the base rate increases. The vertical dashed lines represent the two estimates of the PPV (16% and 47%) we derived for the RPCB. Typically, a positive likelihood ratio between 1 and 2 is considered weak evidence, while ratios between 2 and 10 constitute moderate evidence, and ratios higher than 10 constitute strong evidence. A ratio of less than one indicates that a test is actively uninformative.
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Science Forum: Is preclinical research in cancer biology reproducible enough?
eLife 10:e67527.
https://doi.org/10.7554/eLife.67527
