Neuropsychological evidence of multi-domain network hubs in the human thalamus
- Department of Psychological and Brain Sciences, The University of Iowa & The University of Iowa College of Medicine, United States
- Cognitive Control Collaborative, The University of Iowa & The University of Iowa College of Medicine, United States
- Iowa Neuroscience Institute, The University of Iowa & The University of Iowa College of Medicine, United States
- Department of Psychiatry, The University of Iowa & The University of Iowa College of Medicine, United States
- Brain and Mind Center, The University of Sydney, Australia
- Department of Neurology, The University of Iowa & The University of Iowa College of Medicine, United States
- Department of Pediatrics, The University of Iowa & The University of Iowa College of Medicine, United States
Figures
Figure 1
Thalamic patients performed significantly worse on multiple neuropsychological tests compared to comparison patients.
(A) Overlap of lesions in patients with thalamic lesions and comparison patients with cortical lesions. (B) Neuropsychological test scores from patients with thalamic lesions and comparison …
Figure 2 with 1 supplement
Lesions associated with impaired performance on tasks across multiple cognitive domains.
(A) Left panel: overlap of lesion masks from subjects with impaired test performance on each task. Impaired task performance defined as z < −1.645 (95 percentile in z distribution). Right panel: …
Figure 2—figure supplement 1
Lesion sites of all thalamic patients.
Figure 3 with 1 supplement
Comparing the degree of average behavioral impairment (x axis) and multi-domain behavioral impairment (y axis) between thalamus patients and comparison patients.
More negative average impairment score represents more severe behavioral impairment. Higher multi-domain impairment score indicate more cognitive domains were affected. Individual dots represent …
Figure 3—figure supplement 1
Lesion sites 145 comparison patients.
Figure 4
Neurosynth meta-analyses.
Top four rows: brain regions associated with putative cognitive processes assessed by the Trail Making Test Part B (TMT Part B), Boston Naming Test (BNT), Controlled Oral Word Association Test …
Figure 5
Lesions to thalamic regions with strong hub properties are associated with behavioral impairment across cognitive domains.
(A) Thalamic lesion sites associated with multi-domain impairment are located in the anterior-medio-dorsal thalamus. (B) Right panel: left medial and anterior thalamus is associated with prominent …
Figure 6
Comparison lesions with strong hub properties are associated with behavioral impairment across cognitive domains.
(A) Comparison lesion sites associated with multi-domain impairment are located in the lateral frontal and posterior parietal regions. (B) Frontal and parietal regions exhibit strong connector hub …
Figure 7
The multi-domain lesion site does not show strong functional specificity.
(A) Voxel-wise kernel density plot of thalamocortical functional connectivity weight for each cortical network. Voxels in the multi-domain lesion site exhibit stronger functional connectivity with …
Figure 8
The multi-domain lesion site contains higher concentration of matrix cells.
(A) The anterior-medial thalamus had a relative higher expression of CALB1 (lower panel), which overlapped with the multi-domain lesion sites (upper panel). Color intensity in the lower panel …
Tables
Table 1
Group comparisons on neuropsychological test results.
| Thalamic patients | Comparison patients | ||||
|---|---|---|---|---|---|
| Mean z-score | SD | Mean z-score | SD | Randomized permutation p | |
| Trail Making Test Part A | 0.38 | 1.08 | 0.06 | 1.48 | 0.10 |
| Trail Making Test Part B | –2.15 | 2.94 | 0.3 | 1.55 | <0.001 |
| Boston Naming Task | –0.29 | 0.73 | 0.3 | 0.64 | 0.0033 |
| Controlled Oral Word Association Test | –0.4 | 1.3 | 0.38 | 1.16 | 0.055 |
| Rey Auditory-Verbal Learning | |||||
| Immediate Learning | –0.68 | 0.71 | –0.6 | 0.85 | 0.76 |
| Total Learning | –0.79 | 1.37 | –0.22 | 0.92 | 0.11 |
| Delayed Recall | –0.73 | 1.29 | 0.45 | 0.94 | 0.0021 |
| Delayed Recognition | –1.36 | 2.7 | 0.12 | 0.86 | 0.0049 |
| Rey Complex Figure Test | |||||
| Delayed Recall | –0.16 | 0.86 | 0.094 | 0.94 | 0.41 |
| Copy Test | –0.51 | 1.17 | 0.064 | 0.56 | 0.098 |
Additional files
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Transparent reporting form
- https://cdn.elifesciences.org/articles/69480/elife-69480-transrepform1-v2.docx
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Supplementary file 1
Demographic data for all patients.
- https://cdn.elifesciences.org/articles/69480/elife-69480-supp1-v2.xlsx
