1. Neuroscience
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Neurotransmission: The secret life of memory receptors

  1. Hovy Ho-Wai Wong
  2. Olivier Camiré
  3. P Jesper Sjöström  Is a corresponding author
  1. Centre for Research in Neuroscience, Department of Medicine, The Research Institute of the McGill University Health Centre, Canada
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Cite this article as: eLife 2021;10:e71178 doi: 10.7554/eLife.71178
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Presynaptic NMDA receptors regulate synapse-typespecific neurotransmission.

(A) In the textbook view of central neurotransmission, the presynaptic spike (lightning symbol) elicits the release of a neurotransmitter (e.g., glutamate; green), which binds to postsynaptic glutamate receptors such as NMDARs (blue). (B) However, Lituma et al. found that presynaptic NMDARs (red) in hippocampal mossy fibers facilitate the release of glutamate (green) and a growth factor called BDNF (purple), possibly through an influx of calcium ions (Ca2+; question marks). The released glutamate may further activate presynaptic NMDARs (red) in a form of loop.

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