TY - JOUR TI - Sensing complementary temporal features of odor signals enhances navigation of diverse turbulent plumes AU - Jayaram, Viraaj AU - Kadakia, Nirag AU - Emonet, Thierry A2 - Seminara, Agnese A2 - Calabrese, Ronald L A2 - Riffell, Jeff VL - 11 PY - 2022 DA - 2022/01/24 SP - e72415 C1 - eLife 2022;11:e72415 DO - 10.7554/eLife.72415 UR - https://doi.org/10.7554/eLife.72415 AB - We and others have shown that during odor plume navigation, walking Drosophila melanogaster bias their motion upwind in response to both the frequency of their encounters with the odor (Demir et al., 2020) and the intermittency of the odor signal, which we define to be the fraction of time the signal is above a detection threshold (Alvarez-Salvado et al., 2018). Here, we combine and simplify previous mathematical models that recapitulated these data to investigate the benefits of sensing both of these temporal features and how these benefits depend on the spatiotemporal statistics of the odor plume. Through agent-based simulations, we find that navigators that only use frequency or intermittency perform well in some environments – achieving maximal performance when gains are near those inferred from experiment – but fail in others. Robust performance across diverse environments requires both temporal modalities. However, we also find a steep trade-off when using both sensors simultaneously, suggesting a strong benefit to modulating how much each sensor is weighted, rather than using both in a fixed combination across plumes. Finally, we show that the circuitry of the Drosophila olfactory periphery naturally enables simultaneous intermittency and frequency sensing, enhancing robust navigation through a diversity of odor environments. Together, our results suggest that the first stage of olfactory processing selects and encodes temporal features of odor signals critical to real-world navigation tasks. KW - olfactory navigation KW - turbulence KW - odor plumes KW - olfactory receptor neurons KW - whiff frequency KW - intermittency JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -