TY - JOUR TI - Charting brain growth and aging at high spatial precision AU - Rutherford, Saige AU - Fraza, Charlotte AU - Dinga, Richard AU - Kia, Seyed Mostafa AU - Wolfers, Thomas AU - Zabihi, Mariam AU - Berthet, Pierre AU - Worker, Amanda AU - Verdi, Serena AU - Andrews, Derek AU - Han, Laura KM AU - Bayer, Johanna MM AU - Dazzan, Paola AU - McGuire, Phillip AU - Mocking, Roel T AU - Schene, Aart AU - Sripada, Chandra AU - Tso, Ivy F AU - Duval, Elizabeth R AU - Chang, Soo-Eun AU - Penninx, Brenda WJH AU - Heitzeg, Mary M AU - Burt, S Alexandra AU - Hyde, Luke W AU - Amaral, David AU - Wu Nordahl, Christine AU - Andreasssen, Ole A AU - Westlye, Lars T AU - Zahn, Roland AU - Ruhe, Henricus G AU - Beckmann, Christian AU - Marquand, Andre F A2 - Baker, Chris I A2 - Taschler, Bernd A2 - Esteban, Oscar A2 - Constable, Todd VL - 11 PY - 2022 DA - 2022/02/01 SP - e72904 C1 - eLife 2022;11:e72904 DO - 10.7554/eLife.72904 UR - https://doi.org/10.7554/eLife.72904 AB - Defining reference models for population variation, and the ability to study individual deviations is essential for understanding inter-individual variability and its relation to the onset and progression of medical conditions. In this work, we assembled a reference cohort of neuroimaging data from 82 sites (N=58,836; ages 2–100) and used normative modeling to characterize lifespan trajectories of cortical thickness and subcortical volume. Models are validated against a manually quality checked subset (N=24,354) and we provide an interface for transferring to new data sources. We showcase the clinical value by applying the models to a transdiagnostic psychiatric sample (N=1985), showing they can be used to quantify variability underlying multiple disorders whilst also refining case-control inferences. These models will be augmented with additional samples and imaging modalities as they become available. This provides a common reference platform to bind results from different studies and ultimately paves the way for personalized clinical decision-making. KW - normative model KW - lifespan KW - growth chart KW - brain chart KW - big data KW - individual prediction JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -