TY - JOUR TI - Galvanic current activates the NLRP3 inflammasome to promote Type I collagen production in tendon AU - Peñin-Franch, Alejandro AU - García-Vidal, José Antonio AU - Martínez, Carlos Manuel AU - Escolar-Reina, Pilar AU - Martínez-Ojeda, Rosa M AU - Gómez, Ana I AU - Bueno, Juan M AU - Minaya-Muñoz, Francisco AU - Valera-Garrido, Fermín AU - Medina-Mirapeix, Francesc AU - Pelegrín, Pablo A2 - Abu-Amer, Yousef A2 - Zaidi, Mone VL - 11 PY - 2022 DA - 2022/02/24 SP - e73675 C1 - eLife 2022;11:e73675 DO - 10.7554/eLife.73675 UR - https://doi.org/10.7554/eLife.73675 AB - The NLRP3 inflammasome coordinates inflammation in response to different pathogen- and damage-associated molecular patterns, being implicated in different infectious, chronic inflammatory, metabolic and degenerative diseases. In chronic tendinopathic lesions, different non-resolving mechanisms produce a degenerative condition that impairs tissue healing and which therefore complicates their clinical management. Percutaneous needle electrolysis consists of the application of a galvanic current and is an emerging treatment for tendinopathies. In the present study, we found that galvanic current activates the NLRP3 inflammasome and induces an inflammatory response that promotes a collagen-mediated regeneration of the tendon in mice. This study establishes the molecular mechanism of percutaneous electrolysis that can be used to treat chronic lesions and describes the beneficial effects of an induced inflammasome-related response. KW - percutaneous needle electrolysis KW - tendon KW - tendinopathy KW - inflammasome KW - NLRP3 KW - caspase-1 JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -