TY - JOUR TI - Perception of a conserved family of plant signalling peptides by the receptor kinase HSL3 AU - Rhodes, Jack AU - Roman, Andra-Octavia AU - Bjornson, Marta AU - Brandt, Benjamin AU - Derbyshire, Paul AU - Wyler, Michele AU - Schmid, Marc W AU - Menke, Frank LH AU - Santiago, Julia AU - Zipfel, Cyril A2 - Gutjahr, Caroline A2 - Kleine-Vehn, Jürgen A2 - Gutjahr, Caroline VL - 11 PY - 2022 DA - 2022/05/26 SP - e74687 C1 - eLife 2022;11:e74687 DO - 10.7554/eLife.74687 UR - https://doi.org/10.7554/eLife.74687 AB - Plant genomes encode hundreds of secreted peptides; however, relatively few have been characterised. We report here an uncharacterised, stress-induced family of plant signalling peptides, which we call CTNIPs. Based on the role of the common co-receptor BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED KINASE 1 (BAK1) in CTNIP-induced responses, we identified in Arabidopsis thaliana the orphan receptor kinase HAESA-LIKE 3 (HSL3) as the CTNIP receptor via a proteomics approach. CTNIP-binding, ligand-triggered complex formation with BAK1, and induced downstream responses all involve HSL3. Notably, the HSL3-CTNIP signalling module is evolutionarily conserved amongst most extant angiosperms. The identification of this novel signalling module will further shed light on the diverse functions played by plant signalling peptides and will provide insights into receptor-ligand co-evolution. KW - peptide hormones KW - receptor kinase KW - signalling KW - evolution KW - immunity KW - phytocytokine JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -