1. Computational and Systems Biology
  2. Neuroscience
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Motor Control: Sensory feedback can give rise to neural rotations

  1. Omid G Sani
  2. Maryam M Shanechi  Is a corresponding author
  1. Ming Hsieh Department of Electrical and Computer Engineering, Viterbi School of Engineering, University of Southern California, United States
  2. Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, United States
  3. Neuroscience Graduate Program, University of Southern California, United States
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Cite this article as: eLife 2021;10:e75469 doi: 10.7554/eLife.75469
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Using an artificial network to investigate how rotational patterns are generated in the motor cortex.

(A) The brain and the arm together can be viewed as a closed-loop feedback control system. When the brain receives instructions for a task, neurons in the motor cortex (red inset) send a command to the arm, which moves and returns sensory information back to the cortex. During arm movements, the activity of neurons in the motor cortex exhibits rotational patterns, which may not be visible directly, but usually emerge after neural activity (red graph) has been subjected to dimensionality reduction methods and averaged across several repetitions of the same movement (different movements are shown with different colors). (B) A similar closed-loop system can be constructed in simulations with an artificial neural network (magenta, left) replacing the brain and a musculoskeletal model (right) replacing the arm. Kalidindi et al. show that such a system generates rotational patterns in the artificial neural network that resemble those observed in the motor cortex, regardless of the presence or absence of recurrent connections (purple).

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