TY - JOUR TI - Non-rapid eye movement sleep and wake neurophysiology in schizophrenia AU - Kozhemiako, Nataliia AU - Wang, Jun AU - Jiang, Chenguang AU - Wang, Lei A AU - Gai, Guanchen AU - Zou, Kai AU - Wang, Zhe AU - Yu, Xiaoman AU - Zhou, Lin AU - Li, Shen AU - Guo, Zhenglin AU - Law, Robert AU - Coleman, James AU - Mylonas, Dimitrios AU - Shen, Lu AU - Wang, Guoqiang AU - Tan, Shuping AU - Qin, Shengying AU - Huang, Hailiang AU - Murphy, Michael AU - Stickgold, Robert AU - Manoach, Dara AU - Zhou, Zhenhe AU - Zhu, Wei AU - Hal, Mei-Hua AU - Purcell, Shaun M AU - Pan, Jen Q A2 - Peyrache, Adrien A2 - Büchel, Christian VL - 11 PY - 2022 DA - 2022/05/17 SP - e76211 C1 - eLife 2022;11:e76211 DO - 10.7554/eLife.76211 UR - https://doi.org/10.7554/eLife.76211 AB - Motivated by the potential of objective neurophysiological markers to index thalamocortical function in patients with severe psychiatric illnesses, we comprehensively characterized key non-rapid eye movement (NREM) sleep parameters across multiple domains, their interdependencies, and their relationship to waking event-related potentials and symptom severity. In 72 schizophrenia (SCZ) patients and 58 controls, we confirmed a marked reduction in sleep spindle density in SCZ and extended these findings to show that fast and slow spindle properties were largely uncorrelated. We also describe a novel measure of slow oscillation and spindle interaction that was attenuated in SCZ. The main sleep findings were replicated in a demographically distinct sample, and a joint model, based on multiple NREM components, statistically predicted disease status in the replication cohort. Although also altered in patients, auditory event-related potentials elicited during wake were unrelated to NREM metrics. Consistent with a growing literature implicating thalamocortical dysfunction in SCZ, our characterization identifies independent NREM and wake EEG biomarkers that may index distinct aspects of SCZ pathophysiology and point to multiple neural mechanisms underlying disease heterogeneity. This study lays the groundwork for evaluating these neurophysiological markers, individually or in combination, to guide efforts at treatment and prevention as well as identifying individuals most likely to benefit from specific interventions. KW - schizophrenia KW - wake-sleep KW - EEG KW - sleep spindles KW - auditory ERP KW - connectivity JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -