TY - JOUR TI - Deep learning-based feature extraction for prediction and interpretation of sharp-wave ripples in the rodent hippocampus AU - Navas-Olive, Andrea AU - Amaducci, Rodrigo AU - Jurado-Parras, Maria-Teresa AU - Sebastian, Enrique R AU - de la Prida, Liset M A2 - Peyrache, Adrien A2 - Huguenard, John R VL - 11 PY - 2022 DA - 2022/09/05 SP - e77772 C1 - eLife 2022;11:e77772 DO - 10.7554/eLife.77772 UR - https://doi.org/10.7554/eLife.77772 AB - Local field potential (LFP) deflections and oscillations define hippocampal sharp-wave ripples (SWRs), one of the most synchronous events of the brain. SWRs reflect firing and synaptic current sequences emerging from cognitively relevant neuronal ensembles. While spectral analysis have permitted advances, the surge of ultra-dense recordings now call for new automatic detection strategies. Here, we show how one-dimensional convolutional networks operating over high-density LFP hippocampal recordings allowed for automatic identification of SWR from the rodent hippocampus. When applied without retraining to new datasets and ultra-dense hippocampus-wide recordings, we discovered physiologically relevant processes associated to the emergence of SWR, prompting for novel classification criteria. To gain interpretability, we developed a method to interrogate the operation of the artificial network. We found it relied in feature-based specialization, which permit identification of spatially segregated oscillations and deflections, as well as synchronous population firing typical of replay. Thus, using deep learning-based approaches may change the current heuristic for a better mechanistic interpretation of these relevant neurophysiological events. KW - ripples KW - convolutional neural networks KW - Neuropixels KW - hippocampus KW - dorsoventral JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -