TY - JOUR TI - Information flows from hippocampus to auditory cortex during replay of verbal working memory items AU - Dimakopoulos, Vasileios AU - Mégevand, Pierre AU - Stieglitz, Lennart H AU - Imbach, Lukas AU - Sarnthein, Johannes A2 - Griffiths, Timothy D A2 - Colgin, Laura L VL - 11 PY - 2022 DA - 2022/08/12 SP - e78677 C1 - eLife 2022;11:e78677 DO - 10.7554/eLife.78677 UR - https://doi.org/10.7554/eLife.78677 AB - The maintenance of items in working memory (WM) relies on a widespread network of cortical areas and hippocampus where synchronization between electrophysiological recordings reflects functional coupling. We investigated the direction of information flow between auditory cortex and hippocampus while participants heard and then mentally replayed strings of letters in WM by activating their phonological loop. We recorded local field potentials from the hippocampus, reconstructed beamforming sources of scalp EEG, and – additionally in four participants – recorded from subdural cortical electrodes. When analyzing Granger causality, the information flow was from auditory cortex to hippocampus with a peak in the [4 8] Hz range while participants heard the letters. This flow was subsequently reversed during maintenance while participants maintained the letters in memory. The functional interaction between hippocampus and the cortex and the reversal of information flow provide a physiological basis for the encoding of memory items and their active replay during maintenance. KW - Granger causality KW - phase-locking value KW - auditory cortex KW - theta rhythm JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -