TY - JOUR TI - Non-rapid eye movement sleep determines resilience to social stress AU - Bush, Brittany J AU - Donnay, Caroline AU - Andrews, Eva-Jeneé A AU - Lewis-Sanders, Darielle AU - Gray, Cloe L AU - Qiao, Zhimei AU - Brager, Allison J AU - Johnson, Hadiya AU - Brewer, Hamadi CS AU - Sood, Sahil AU - Saafir, Talib AU - Benveniste, Morris AU - Paul, Ketema N AU - Ehlen, J Christopher A2 - Hill, Matthew N A2 - Wassum, Kate M A2 - Pocivavsek, Ana VL - 11 PY - 2022 DA - 2022/09/23 SP - e80206 C1 - eLife 2022;11:e80206 DO - 10.7554/eLife.80206 UR - https://doi.org/10.7554/eLife.80206 AB - Resilience, the ability to overcome stressful conditions, is found in most mammals and varies significantly among individuals. A lack of resilience can lead to the development of neuropsychiatric and sleep disorders, often within the same individual. Despite extensive research into the brain mechanisms causing maladaptive behavioral-responses to stress, it is not clear why some individuals exhibit resilience. To examine if sleep has a determinative role in maladaptive behavioral-response to social stress, we investigated individual variations in resilience using a social-defeat model for male mice. Our results reveal a direct, causal relationship between sleep amount and resilience—demonstrating that sleep increases after social-defeat stress only occur in resilient mice. Further, we found that within the prefrontal cortex, a regulator of maladaptive responses to stress, pre-existing differences in sleep regulation predict resilience. Overall, these results demonstrate that increased NREM sleep, mediated cortically, is an active response to social-defeat stress that plays a determinative role in promoting resilience. They also show that differences in resilience are strongly correlated with inter-individual variability in sleep regulation. KW - sleep KW - non-rapid eye movement KW - social defeat stress KW - stress KW - resilience KW - social avoidance JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -