TY - JOUR TI - Evolutionary shaping of human brain dynamics AU - Pang, James C AU - Rilling, James K AU - Roberts, James A AU - van den Heuvel, Martijn P AU - Cocchi, Luca A2 - Hilgetag, Claus A2 - Büchel, Christian A2 - Misic, Bratislav VL - 11 PY - 2022 DA - 2022/10/26 SP - e80627 C1 - eLife 2022;11:e80627 DO - 10.7554/eLife.80627 UR - https://doi.org/10.7554/eLife.80627 AB - The human brain is distinct from those of other species in terms of size, organization, and connectivity. How do structural evolutionary differences drive patterns of neural activity enabling brain function? Here, we combine brain imaging and biophysical modeling to show that the anatomical wiring of the human brain distinctly shapes neural dynamics. This shaping is characterized by a narrower distribution of dynamic ranges across brain regions compared with that of chimpanzees, our closest living primate relatives. We find that such a narrow dynamic range distribution supports faster integration between regions, particularly in transmodal systems. Conversely, a broad dynamic range distribution as seen in chimpanzees facilitates brain processes relying more on neural interactions within specialized local brain systems. These findings suggest that human brain dynamics have evolved to foster rapid associative processes in service of complex cognitive functions and behavior. KW - brain dynamics KW - evolution KW - connectome KW - computational modeling KW - chimpanzee JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -