TY - JOUR TI - Distinct population and single-neuron selectivity for executive and episodic processing in human dorsal posterior cingulate AU - Aponik-Gremillion, Lyndsey AU - Chen, Yvonne Y AU - Bartoli, Eleonora AU - Koslov, Seth R AU - Rey, Hernan G AU - Weiner, Kevin S AU - Yoshor, Daniel AU - Hayden, Benjamin Y AU - Sheth, Sameer A AU - Foster, Brett L A2 - Irish, Muireann A2 - Behrens, Timothy E A2 - Leech, Robert A2 - Funk, Xaver VL - 11 PY - 2022 DA - 2022/09/28 SP - e80722 C1 - eLife 2022;11:e80722 DO - 10.7554/eLife.80722 UR - https://doi.org/10.7554/eLife.80722 AB - Posterior cingulate cortex (PCC) is an enigmatic region implicated in psychiatric and neurological disease, yet its role in cognition remains unclear. Human studies link PCC to episodic memory and default mode network (DMN), while findings from the non-human primate emphasize executive processes more associated with the cognitive control network (CCN) in humans. We hypothesized this difference reflects an important functional division between dorsal (executive) and ventral (episodic) PCC. To test this, we utilized human intracranial recordings of population and single unit activity targeting dorsal PCC during an alternated executive/episodic processing task. Dorsal PCC population responses were significantly enhanced for executive, compared to episodic, task conditions, consistent with the CCN. Single unit recordings, however, revealed four distinct functional types with unique executive (CCN) or episodic (DMN) response profiles. Our findings provide critical electrophysiological data from human PCC, bridging incongruent views within and across species, furthering our understanding of PCC function. KW - ieeg KW - episodic memory KW - default network KW - posterior cingulate KW - executive function KW - cognitive control network JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -